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Invitrogen
SUR1 Monoclonal Antibody (N289/16)
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FIGURE: 1 / 2
SUR1 Antibody (MA5-27660) in ICC/IF
Immunofluorescent analysis of SUR1 in human neuroblastoma cell line (SK-N-BE). Sample was fixed with 4% formaldehyde (15 min at RT), incubated with SUR1 monoclonal antibody (Product # MA5-27660) using a dilution of 1:100 (1 hour at RT), and followed by Goat Anti-Mouse 488, Phalloidin Texas Red and DAPI secondary antibody at a dilution of 1:100, 1:1000 (60 min at RT) and 1:5000 (5 min at RT). Images are shown as follows: (A) DAPI (blue) nuclear stain, B) Phalloidin Texas Red F-Actin stain, C) SUR1 Antibody, D) Merged image. Magnification: 6... View More
Product Details
MA5-27660
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Hamster,
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
N289/16
Immunogen
Fusion protein amino acids 1548-1582 (cytoplasmic C-terminus) of rat SUR1
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
1 µg/mL of MA5-27660 was sufficient for detection of SUR1 in 20 µg of mouse brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.|Detects approximately 160kDa. Does not cross-react with SUR2B.
This antibody was formerly sold as clone S289-16.
Target Information
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies. This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed; however, the transcript variants have not been fully described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AM60008PU-N; ATP-binding cassette sub-family C member 8; ATP-binding cassette transporter sub-family C member 8; ATP-binding cassette, sub-family C (CFTR/MRP), member 8; PH SUR1; sulfonylurea receptor; sulfonylurea receptor (hyperinsulinemia); Sulfonylurea receptor 1; sulphonylurea receptor 1; unnamed protein product
Gene Aliases: ABC36; ABCC8; D930031B21Rik; HHF1; HI; HRINS; MODY12; MRP8; PHHI; PNDM3; SUR; SUR1; SUR1delta2; TNDM2
UniProt ID: (Human) Q09428, (Rat) Q09429
Entrez Gene ID: (Human) 6833, (Mouse) 20927, (Rat) 25559, (Chinese hamster) 100764394
nucleotide binding
potassium channel activity
protein binding
ATP binding
sulfonylurea receptor activity
ATP-activated inward rectifier potassium channel activity
ATPase activity
cation-transporting ATPase activity
ADP binding
ion channel binding
metal ion binding
ABC-type transporter activity
syntaxin binding
ATPase activity, coupled to transmembrane movement of substances
ATP-binding cassette (ABC) transporter
action potential
cellular glucose homeostasis
potassium ion transport
female pregnancy
memory
visual learning
response to pH
response to xenobiotic stimulus
response to zinc ion
negative regulation of low-density lipoprotein particle clearance
negative regulation of angiogenesis
cellular response to nutrient levels
response to lipopolysaccharide
positive regulation of tumor necrosis factor production
response to insulin
positive regulation of insulin secretion involved in cellular response to glucose stimulus
positive regulation of potassium ion transport
negative regulation of insulin secretion
negative regulation of neurogenesis
neuromuscular process
transmembrane transport
negative regulation of glial cell proliferation
glutamate secretion, neurotransmission
negative regulation of neuroblast migration
potassium ion transmembrane transport
inorganic cation transmembrane transport
positive regulation of uterine smooth muscle relaxation
positive regulation of occluding junction disassembly
negative regulation of blood-brain barrier permeability
potassium ion import across plasma membrane
cellular response to organic substance
signal transduction
metabolic process
response to drug
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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