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Invitrogen
SUR1 Monoclonal Antibody (N289/16), FITC
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FIGURE: 1 / 3
SUR1 Antibody (MA5-45559) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis using human neuroblastoma cells. Fixation involved 4% Formaldehyde for 15 min at RT. Samples were incubated with SUR1 monoclonal antibody (Product # MA5-45559) at 1:100 for 60 min at RT, followed by Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain used was Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1,000, 1:5,000 for 60 min RT, 5 min RT. Localization: Cytoplasm, Nucleus. Magnification: 60X. (A) DAPI (blue) nuclear stain. (B) Phalloidin Texas Red F-Actin... View More
Product Details
MA5-45559
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Hamster,
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
N289/16
Immunogen
Fusion protein amino acids 1548-1582 (cytoplasmic C-terminus) of rat SUR1
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
9.09mM sodium bicarbonate/PBS, pH 7.4, with 640.91mM DMSO, 136.36mM ethanolamine
Contains
no preservative
Storage conditions
4°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
1 µg/mL of MA5-45559 was sufficient for detection of SUR1 in 20 µg of mouse brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.|Detects approximately 160kDa. Does not cross-react with SUR2B.
This antibody was formerly sold as clone S289-16.
Target Information
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies. This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed; however, the transcript variants have not been fully described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AM60008PU-N; ATP-binding cassette sub-family C member 8; ATP-binding cassette transporter sub-family C member 8; ATP-binding cassette, sub-family C (CFTR/MRP), member 8; PH SUR1; sulfonylurea receptor; sulfonylurea receptor (hyperinsulinemia); Sulfonylurea receptor 1; sulphonylurea receptor 1
Gene Aliases: ABC36; ABCC8; D930031B21Rik; HHF1; HI; HRINS; MRP8; PHHI; SUR; SUR1; SUR1delta2; TNDM2
UniProt ID: (Human) Q09428, (Rat) Q09429
Entrez Gene ID: (Human) 6833, (Mouse) 20927, (Rat) 25559, (Chinese hamster) 100764394
potassium channel activity
ATP binding
sulfonylurea receptor activity
ATP-activated inward rectifier potassium channel activity
syntaxin binding
anion transmembrane-transporting ATPase activity
ion channel binding
ATPase activity, coupled to transmembrane movement of substances
ATP-binding cassette (ABC) transporter
potassium ion transport
signal transduction
response to pH
response to zinc ion
response to lipopolysaccharide
response to insulin
response to drug
positive regulation of potassium ion transport
negative regulation of insulin secretion
regulation of insulin secretion
transmembrane transport
cellular response to organic substance
potassium ion transmembrane transport
anion transmembrane transport
metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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