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Invitrogen

SUR1 Monoclonal Antibody (N289/16), PE

View all (27) SUR1 antibodies

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SUR1 Monoclonal Antibody (N289/16), PE

Product Details

MA5-45561

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (IHC)

1:1,000
-

Immunocytochemistry (ICC/IF)

1:100
-
Product Specifications

Species Reactivity

Hamster, Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

N289/16

Immunogen

Fusion protein amino acids 1548-1582 (cytoplasmic C-terminus) of rat SUR1
View immunogen

Conjugate

PE PE PE

Excitation/Emission Max

565/576 nm View spectra spectra

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

95.64mM phosphate/2.48mM MES, pH 7.4, with 0.5M EDTA

Contains

no preservative

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2932015

Product Specific Information

1 µg/mL of MA5-45561 was sufficient for detection of SUR1 in 20 µg of mouse brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.|Detects approximately 160kDa. Does not cross-react with SUR2B.

This antibody was formerly sold as clone S289-16.

Target Information

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies. This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed; however, the transcript variants have not been fully described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: AM60008PU-N; ATP-binding cassette sub-family C member 8; ATP-binding cassette transporter sub-family C member 8; ATP-binding cassette, sub-family C (CFTR/MRP), member 8; PH SUR1; sulfonylurea receptor; sulfonylurea receptor (hyperinsulinemia); Sulfonylurea receptor 1; sulphonylurea receptor 1; unnamed protein product

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Gene Aliases: ABC36; ABCC8; D930031B21Rik; HHF1; HI; HRINS; MODY12; MRP8; PHHI; PNDM3; SUR; SUR1; SUR1delta2; TNDM2

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UniProt ID: (Human) Q09428, (Rat) Q09429

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Entrez Gene ID: (Human) 6833, (Mouse) 20927, (Rat) 25559, (Chinese hamster) 100764394

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Function(s)
nucleotide binding potassium channel activity protein binding ATP binding sulfonylurea receptor activity ATP-activated inward rectifier potassium channel activity ATPase activity cation-transporting ATPase activity ADP binding ion channel binding metal ion binding ABC-type transporter activity syntaxin binding ATPase activity, coupled to transmembrane movement of substances ATP-binding cassette (ABC) transporter
Process(es)
action potential cellular glucose homeostasis potassium ion transport female pregnancy memory visual learning response to pH response to xenobiotic stimulus response to zinc ion negative regulation of low-density lipoprotein particle clearance negative regulation of angiogenesis cellular response to nutrient levels response to lipopolysaccharide positive regulation of tumor necrosis factor production response to insulin positive regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of potassium ion transport negative regulation of insulin secretion negative regulation of neurogenesis neuromuscular process transmembrane transport negative regulation of glial cell proliferation glutamate secretion, neurotransmission negative regulation of neuroblast migration potassium ion transmembrane transport inorganic cation transmembrane transport positive regulation of uterine smooth muscle relaxation positive regulation of occluding junction disassembly negative regulation of blood-brain barrier permeability potassium ion import across plasma membrane cellular response to organic substance signal transduction metabolic process response to drug
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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