Search

  • Fale Conosco
  • Pedido rápido

Invitrogen

KCNQ1 Monoclonal Antibody (N37A/10)

1 Reference
View all (24) KCNQ1 antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
KCNQ1 Monoclonal Antibody (N37A/10)

Product Details

MA5-27676

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:1,000
-

Immunocytochemistry (ICC/IF)

1:100
-

Immunoprecipitation (IP)

25 µg
-

Antibody Microarray (Ab Microarray)

Assay-dependent
-
Product Specifications

Species Reactivity

Hamster, Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

N37A/10

Immunogen

Fusion protein amino acids 2-101 of human KCNQ1
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.09% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2735245

Product Specific Information

1 µg/mL of MA5-27676 was sufficient for detection of KCNQ1 in 10 µg of COS-1 cell lysate transiently expressing KCNQ1 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.|Detects approximately 75kDa.

Target Information

Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. A specific K+ channel, comprised of an alpha subunit KCNQ1 and a beta subunit KCNE1, a small protein which spans the membrane only once, is predominantly expressed in the heart and in the cochlea, and is responsible for regulating the slow, depolarization-activated potassium current. Mutations in the genes encoding for KCNQ1 and KCNE1 lead to cardiac disease because they directly impair electrical signaling, and mutations in KCNQ4 are implicated in the onset of deafness. KCNQ proteins, including KCNQ1 and KCNQ4, characteristically contain six transmembrane domains and function as tetramers. KCNQ4 forms heteromeric channels with KCNQ3 and is expressed in several tissues, including the cochlea, where it is present in outer hair cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: FLJ26167; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; Kcnq1; kidney and cardiac voltage dependend K+ channel; KQT-like 1; KQT-like subfamily member 1; potassium channel, voltage gated KQT-like subfamily Q, member 1; potassium channel, voltage-gated KQT-like subfamily Q, member 1; Potassium voltage-gated channel subfamily KQT member 1; potassium voltage-gated channel, KQT-like subfamily, member 1; potassium voltage-gated channel, subfamily Q, member 1; slow delayed rectifier channel subunit; tKvLQT1; unnamed protein product; voltage-gated potassium channel subunit Kv7.1

View more View less

Gene Aliases: ATFB1; ATFB3; I79_015904; JLNS1; KCNA8; KCNA9; Kv1.9; Kv7.1; KVLQT1; LQT; LQT1; RWS; SQT2; WRS

View more View less

UniProt ID: (Human) P51787, (Rat) Q9Z0N7, (Mouse) P97414

View more View less

Entrez Gene ID: (Human) 3784, (Rat) 84020, (Chinese hamster) 100761481, (Mouse) 16535

View more View less

Function(s)
ion channel activity voltage-gated potassium channel activity delayed rectifier potassium channel activity protein binding calmodulin binding phosphatidylinositol-4,5-bisphosphate binding protein phosphatase 1 binding outward rectifier potassium channel activity ubiquitin protein ligase binding protein kinase A catalytic subunit binding protein kinase A regulatory subunit binding ion channel binding voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization scaffold protein binding voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization potassium channel activity identical protein binding voltage-gated ion channel
Process(es)
action potential gastric acid secretion gastrin-induced gastric acid secretion regulation of heart rate system process glucose metabolic process ion transport potassium ion transport sodium ion transport heart development sensory perception of sound rhythmic behavior regulation of heart contraction regulation of blood pressure positive regulation of heart rate iodide transport erythrocyte differentiation cellular chloride ion homeostasis response to insulin social behavior corticosterone secretion regulation of membrane potential inner ear morphogenesis inner ear development intestinal absorption neuromuscular process detection of mechanical stimulus involved in sensory perception of sound regulation of transport chloride ion homeostasis potassium ion homeostasis transmembrane transport cardiac muscle contraction auditory receptor cell development regulation of membrane repolarization regulation of ventricular cardiac muscle cell membrane repolarization regulation of atrial cardiac muscle cell membrane repolarization positive regulation of cardiac muscle contraction regulation of gastric acid secretion cardiac conduction stomach development renal absorption renal sodium ion absorption cellular response to cAMP cellular response to xenobiotic stimulus potassium ion transmembrane transport cellular response to epinephrine stimulus adrenergic receptor signaling pathway cardiac muscle cell contraction ventricular cardiac muscle cell action potential membrane repolarization membrane repolarization during action potential membrane repolarization during cardiac muscle cell action potential atrial cardiac muscle cell action potential regulation of heart rate by cardiac conduction cochlea development potassium ion export across plasma membrane membrane repolarization during atrial cardiac muscle cell action potential membrane repolarization during ventricular cardiac muscle cell action potential positive regulation of potassium ion transmembrane transport negative regulation of delayed rectifier potassium channel activity negative regulation of voltage-gated potassium channel activity non-motile cilium assembly potassium ion import across plasma membrane male gonad development regulation of hormone levels digestive system process negative regulation of insulin secretion response to anesthetic regulation of voltage-gated sodium channel activity
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support