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Invitrogen

KCNQ1 Monoclonal Antibody (N37A/10), FITC

View all (24) KCNQ1 antibodies

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KCNQ1 Monoclonal Antibody (N37A/10), FITC

Product Details

MA5-45408

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:1,000
-

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:1,000
-

Immunocytochemistry (ICC/IF)

1:100
-

Immunoprecipitation (IP)

Assay-dependent
-

Antibody Microarray (Ab Microarray)

Assay-dependent
-
Product Specifications

Species Reactivity

Hamster, Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

N37A/10

Immunogen

Fusion protein amino acids 2-101 of human KCNQ1
3D Epitope / Immunogen

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra spectra

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

9.1mM sodium bicarbonate/PBS, pH 7.4, with 640.91mM DMSO, 136.36mM ethanolamine

Contains

no preservative

Storage conditions

4°C, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2931862

Product Specific Information

1 µg/mL of MA5-45408 was sufficient for detection of KCNQ1 in 10 µg of COS-1 cell lysate transiently expressing KCNQ1 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.|Detects approximately 75kDa.

Target Information

Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. A specific K+ channel, comprised of an alpha subunit KCNQ1 and a beta subunit KCNE1, a small protein which spans the membrane only once, is predominantly expressed in the heart and in the cochlea, and is responsible for regulating the slow, depolarization-activated potassium current. Mutations in the genes encoding for KCNQ1 and KCNE1 lead to cardiac disease because they directly impair electrical signaling, and mutations in KCNQ4 are implicated in the onset of deafness. KCNQ proteins, including KCNQ1 and KCNQ4, characteristically contain six transmembrane domains and function as tetramers. KCNQ4 forms heteromeric channels with KCNQ3 and is expressed in several tissues, including the cochlea, where it is present in outer hair cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: FLJ26167; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; kidney and cardiac voltage dependend K+ channel; KQT-like 1; potassium channel, voltage gated KQT-like subfamily Q, member 1; Potassium voltage-gated channel subfamily KQT member 1; potassium voltage-gated channel, KQT-like subfamily, member 1; potassium voltage-gated channel, subfamily Q, member 1; slow delayed rectifier channel subunit; tKvLQT1; unnamed protein product; Voltage-gated potassium channel subunit Kv7.1

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Gene Aliases: ATFB1; ATFB3; AW559127; I79_015904; JLNS1; KCNA8; KCNA9; KCNQ1; Kv1.9; Kv7.1; KVLQT1; LQT; LQT1; RWS; SQT2; WRS

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UniProt ID: (Human) P51787, (Mouse) P97414, (Rat) Q9Z0N7

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Entrez Gene ID: (Human) 3784, (Mouse) 16535, (Chinese hamster) 100761481, (Rat) 84020

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Function(s)
ion channel activity voltage-gated potassium channel activity delayed rectifier potassium channel activity potassium channel activity protein binding calmodulin binding phosphatidylinositol-4,5-bisphosphate binding protein phosphatase 1 binding outward rectifier potassium channel activity ubiquitin protein ligase binding protein kinase A catalytic subunit binding protein kinase A regulatory subunit binding ion channel binding voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization scaffold protein binding voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization voltage-gated ion channel activity protein homodimerization activity voltage-gated ion channel
Process(es)
action potential gastric acid secretion gastrin-induced gastric acid secretion regulation of heart rate system process glucose metabolic process ion transport potassium ion transport sodium ion transport heart development sensory perception of sound rhythmic behavior regulation of heart contraction regulation of blood pressure positive regulation of heart rate iodide transport digestive system process erythrocyte differentiation cellular chloride ion homeostasis response to insulin ion transmembrane transport social behavior corticosterone secretion regulation of membrane potential inner ear morphogenesis inner ear development intestinal absorption detection of mechanical stimulus involved in sensory perception of sound regulation of transport chloride ion homeostasis potassium ion homeostasis transmembrane transport cardiac muscle contraction auditory receptor cell development regulation of membrane repolarization regulation of ventricular cardiac muscle cell membrane repolarization regulation of atrial cardiac muscle cell membrane repolarization positive regulation of cardiac muscle contraction regulation of gastric acid secretion cardiac conduction stomach development renal absorption renal sodium ion absorption cellular response to cAMP cellular response to xenobiotic stimulus potassium ion transmembrane transport cellular response to epinephrine stimulus adrenergic receptor signaling pathway cardiac muscle cell contraction ventricular cardiac muscle cell action potential membrane repolarization membrane repolarization during action potential membrane repolarization during cardiac muscle cell action potential atrial cardiac muscle cell action potential regulation of heart rate by cardiac conduction cochlea development potassium ion export across plasma membrane membrane repolarization during atrial cardiac muscle cell action potential membrane repolarization during ventricular cardiac muscle cell action potential positive regulation of potassium ion transmembrane transport negative regulation of delayed rectifier potassium channel activity negative regulation of voltage-gated potassium channel activity non-motile cilium assembly potassium ion import across plasma membrane positive regulation of defense response to virus by host regulation of gene expression by genetic imprinting transport gene silencing regulation of ion transmembrane transport cellular response to drug negative regulation of insulin secretion positive regulation of gastric acid secretion potassium ion export response to anesthetic cardiovascular system development male gonad development
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