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Invitrogen

CD243 (ABCB1) Monoclonal Antibody (UIC2)

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CD243 (ABCB1) Monoclonal Antibody (UIC2)

Product Details

MA5-28587

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

Assay-Dependent
-

Immunohistochemistry (Frozen) (IHC (F))

Assay-Dependent
-

Flow Cytometry (Flow)

1-4 µg/mL
-

Immunoprecipitation (IP)

Assay-Dependent
-

Functional Assay (Functional)

Assay-Dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

UIC2

Immunogen

Human CD243 (MDR-1) cDNA- transfected NIH 3T3 cells
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

4°C, do not freeze

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2745546

Product Specific Information

This antibody recognizes an extracellular epitope on CD243 (MDR-1), an approximately 170 kDa ABC transporter expressed on hematopoietic stem cells, B, T, and NK cells, or on many multidrug resistant cancer cells.

This antibody preferentially recognizes CD243 in the process of transporting substrate. Low endotoxin azide free phosphate buffered saline (PBS) solution, 0.2 µm filter sterilized.

Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.

Immunohistochemistry (Paraffin): Heat mediated antigen retrieval in citrate buffer pH 6; Functional Application: Inhibition.

Target Information

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ATP-binding cassette sub-family B member 1; ATP-binding cassette, sub-family B (MDR/TAP), member 1; ATP-dependent translocase ABCB1; CD243; colchicin sensitivity; doxorubicin resistance; MDR1; P-glycoprotein; Multidrug resistance protein 1; multidrug-resistance; P-glycoprotein; P-glycoprotein 1; Phospholipid transporter ABCB1; unnamed protein product; uORF

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Gene Aliases: ABC20; ABCB1; CD243; CLCS; ENPAT; GP170; MDR1; p-170; P-GP; PGY1

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UniProt ID: (Human) P08183

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Entrez Gene ID: (Human) 5243

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Function(s)
nucleotide binding protein binding ATP binding xenobiotic-transporting ATPase activity efflux transmembrane transporter activity ATPase activity transmembrane transporter activity ubiquitin protein ligase binding ATPase activity, coupled to transmembrane movement of substances xenobiotic transporter activity carboxylic acid transmembrane transporter activity phosphatidylcholine-translocating ATPase activity phosphatidylethanolamine flippase activity ceramide floppase activity ATPase-coupled intramembrane lipid transporter activity floppase activity ABC-type transporter activity
Process(es)
G2/M transition of mitotic cell cycle response to hypoxia placenta development xenobiotic metabolic process lipid transport female pregnancy lactation circadian rhythm response to xenobiotic stimulus hormone transport response to mycotoxin response to nutrient levels response to estradiol response to lipopolysaccharide response to progesterone response to vitamin A response to vitamin D response to glucagon maintenance of blood-brain barrier cellular response to mycotoxin daunorubicin transport phospholipid translocation response to cadmium ion terpenoid transport intestinal absorption transmembrane transport establishment of blood-brain barrier transepithelial transport cellular response to external biotic stimulus cellular response to lipopolysaccharide cellular response to antibiotic cellular response to alkaloid cellular response to tumor necrosis factor cellular response to estradiol stimulus cellular hyperosmotic salinity response response to dexamethasone cellular response to dexamethasone stimulus stem cell proliferation response to thyroxine response to alcohol response to antineoplastic agent ceramide translocation export across plasma membrane transport across blood-brain barrier response to L-glutamate protein localization to bicellular tight junction response to glycoside negative regulation of sensory perception of pain cellular response to nonylphenol positive regulation of establishment of Sertoli cell barrier regulation of intestinal absorption carboxylic acid transmembrane transport cellular response to borneol cellular response to L-glutamate response to codeine response to quercetin response to cyclosporin A drug transmembrane export drug transport across blood-brain barrier establishment of blood-retinal barrier positive regulation of response to drug regulation of chloride transport
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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