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Invitrogen
CD243 (ABCB1) Monoclonal Antibody (UIC2)
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Product Details
MA5-28587
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
UIC2
Immunogen
Human CD243 (MDR-1) cDNA- transfected NIH 3T3 cells
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody recognizes an extracellular epitope on CD243 (MDR-1), an approximately 170 kDa ABC transporter expressed on hematopoietic stem cells, B, T, and NK cells, or on many multidrug resistant cancer cells.
This antibody preferentially recognizes CD243 in the process of transporting substrate. Low endotoxin azide free phosphate buffered saline (PBS) solution, 0.2 µm filter sterilized.
Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.
Immunohistochemistry (Paraffin): Heat mediated antigen retrieval in citrate buffer pH 6; Functional Application: Inhibition.
Target Information
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-binding cassette sub-family B member 1; ATP-binding cassette, sub-family B (MDR/TAP), member 1; ATP-dependent translocase ABCB1; CD243; colchicin sensitivity; doxorubicin resistance; MDR1; P-glycoprotein; Multidrug resistance protein 1; multidrug-resistance; P-glycoprotein; P-glycoprotein 1; Phospholipid transporter ABCB1; unnamed protein product; uORF
Gene Aliases: ABC20; ABCB1; CD243; CLCS; ENPAT; GP170; MDR1; p-170; P-GP; PGY1
UniProt ID: (Human) P08183
Entrez Gene ID: (Human) 5243
nucleotide binding
protein binding
ATP binding
xenobiotic-transporting ATPase activity
efflux transmembrane transporter activity
ATPase activity
transmembrane transporter activity
ubiquitin protein ligase binding
ATPase activity, coupled to transmembrane movement of substances
xenobiotic transporter activity
carboxylic acid transmembrane transporter activity
phosphatidylcholine-translocating ATPase activity
phosphatidylethanolamine flippase activity
ceramide floppase activity
ATPase-coupled intramembrane lipid transporter activity
floppase activity
ABC-type transporter activity
G2/M transition of mitotic cell cycle
response to hypoxia
placenta development
xenobiotic metabolic process
lipid transport
female pregnancy
lactation
circadian rhythm
response to xenobiotic stimulus
hormone transport
response to mycotoxin
response to nutrient levels
response to estradiol
response to lipopolysaccharide
response to progesterone
response to vitamin A
response to vitamin D
response to glucagon
maintenance of blood-brain barrier
cellular response to mycotoxin
daunorubicin transport
phospholipid translocation
response to cadmium ion
terpenoid transport
intestinal absorption
transmembrane transport
establishment of blood-brain barrier
transepithelial transport
cellular response to external biotic stimulus
cellular response to lipopolysaccharide
cellular response to antibiotic
cellular response to alkaloid
cellular response to tumor necrosis factor
cellular response to estradiol stimulus
cellular hyperosmotic salinity response
response to dexamethasone
cellular response to dexamethasone stimulus
stem cell proliferation
response to thyroxine
response to alcohol
response to antineoplastic agent
ceramide translocation
export across plasma membrane
transport across blood-brain barrier
response to L-glutamate
protein localization to bicellular tight junction
response to glycoside
negative regulation of sensory perception of pain
cellular response to nonylphenol
positive regulation of establishment of Sertoli cell barrier
regulation of intestinal absorption
carboxylic acid transmembrane transport
cellular response to borneol
cellular response to L-glutamate
response to codeine
response to quercetin
response to cyclosporin A
drug transmembrane export
drug transport across blood-brain barrier
establishment of blood-retinal barrier
positive regulation of response to drug
regulation of chloride transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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