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Invitrogen
ABCB1 Monoclonal Antibody (UIC2), PE
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA574201
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
UIC2
Immunogen
NIH 3T3 cells transfected with human CD243 (MDR-1) cDNA.
Conjugate
PE
PE
PE
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Purification
Size-exclusion chromatography
Storage buffer
PBS, pH 7.4, with 0.2% BSA
Contains
15mM sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-binding cassette, sub-family B (MDR/TAP), member 1; colchicin sensitivity; doxorubicin resistance; MDR1; P-glycoprotein; multidrug resistance protein 1; multidrug-resistance; P-glycoprotein; P-glycoprotein 1; phospholipid transporter ABCB1; unnamed protein product; uORF
Gene Aliases: ABC20; CD243; CLCS; ENPAT; GP170; MDR1; p-170; P-GP; PGY1
UniProt ID: (Human) P08183
Entrez Gene ID: (Human) 5243
protein binding
ATP binding
xenobiotic-transporting ATPase activity
efflux transmembrane transporter activity
ATPase activity
transmembrane transporter activity
ubiquitin protein ligase binding
ATPase activity, coupled to transmembrane movement of substances
xenobiotic transporter activity
carboxylic acid transmembrane transporter activity
phosphatidylcholine-translocating ATPase activity
phosphatidylethanolamine flippase activity
ceramide floppase activity
ATPase-coupled intramembrane lipid transporter activity
floppase activity
phosphatidylethanolamine floppase activity
ABC-type transporter activity
G2/M transition of mitotic cell cycle
xenobiotic metabolic process
response to xenobiotic stimulus
phospholipid translocation
terpenoid transport
transmembrane transport
transepithelial transport
stem cell proliferation
ceramide translocation
export across plasma membrane
transport across blood-brain barrier
carboxylic acid transmembrane transport
drug transmembrane export
drug transport across blood-brain barrier
regulation of chloride transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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