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Invitrogen

CD117 (c-Kit) Monoclonal Antibody (kit2c75), Biotin

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Product Details

MA5-28803

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

1 µg/10^6 cells
-
Product Specifications

Species Reactivity

Chicken

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

kit2c75

Immunogen

Sp/chkit4A4 cells (Sp2/0 cells transfected with chicken c-Kit cDNA)

Conjugate

Biotin Biotin Biotin

Form

Liquid

Concentration

0.5 mg/mL

Amount

500 µg

Purification

purified

Storage buffer

PBS, pH 7.4, with proprietary stabilizer

Contains

<0.1% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2745762

Target Information

KIT (c-KIT) is a proto-oncogene and a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). KIT was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT together with its ligand regulates growth and activation of a variety of hemopoietic and non-hemopoietic cells. Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Recently, deregulation of the KIT receptor TK by the prevalent activation loop mutation D816V has served as a focal point in therapeutic strategies aimed at curbing neoplastic mast cell growth. c-Kit is expressed in hematopoietic stem cells, germ cells, mast cells and gastrointestinal tract cajal cells. Upon binding of its ligand stem cell factor (SCF), c-kit dimerizes, resulting in receptor activation and autophosphorylation of various tyrosine residues including tyrosine 703 located on the cytoplasmic domain of the receptor. This modification allows docking of Grb2 and activation of the Ras/ERK signaling pathway. SCF/c-kit can activate multiple downstream signaling pathways including PI3K, PLC-gamma and JAK/STAT. c-kit receptor activation is essential for hematopoiesis, stem cell maintenance and gametogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: c-kit; ckit; Mast/stem cell growth factor receptor Kit; Proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; SCFR; Tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

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Gene Aliases: KIT; SCFR

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UniProt ID: (Chicken) Q08156

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Entrez Gene ID: (Chicken) 378783

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Function(s)
protease binding transmembrane receptor protein tyrosine kinase activity stem cell factor receptor activity ATP binding cytokine binding SH2 domain binding protein homodimerization activity metal ion binding transmembrane signal receptor
Process(es)
activation of MAPK activity ovarian follicle development hematopoietic progenitor cell differentiation myeloid progenitor cell differentiation lymphoid progenitor cell differentiation immature B cell differentiation dendritic cell cytokine production mast cell chemotaxis glycosphingolipid metabolic process inflammatory response transmembrane receptor protein tyrosine kinase signaling pathway multicellular organism development spermatid development positive regulation of cell proliferation regulation of cell shape male gonad development response to radiation positive regulation of gene expression peptidyl-tyrosine phosphorylation lamellipodium assembly B cell differentiation T cell differentiation erythrocyte differentiation melanocyte differentiation positive regulation of cell migration actin cytoskeleton reorganization mast cell cytokine production positive regulation of kinase activity embryonic hemopoiesis ectopic germ cell programmed cell death intracellular signal transduction hematopoietic stem cell migration megakaryocyte development Fc receptor signaling pathway Kit signaling pathway erythropoietin-mediated signaling pathway positive regulation of tyrosine phosphorylation of STAT protein negative regulation of programmed cell death mast cell degranulation positive regulation of MAP kinase activity positive regulation of JAK-STAT cascade protein autophosphorylation digestive tract development stem cell differentiation detection of mechanical stimulus involved in sensory perception of sound positive regulation of sequence-specific DNA binding transcription factor activity mast cell differentiation cellular response to thyroid hormone stimulus melanocyte migration melanocyte adhesion positive regulation of vascular smooth muscle cell differentiation
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