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Invitrogen
CD117 (c-Kit) Monoclonal Antibody (kit2c75)
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Product Details
MA5-28806
Product Specifications
Species Reactivity
Chicken
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
kit2c75
Immunogen
Sp/chkit4A4 cells (Sp2/0 cells transfected with chicken c-Kit cDNA)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
500 µg
Purification
purified
Storage buffer
BBS, pH 8.2
Contains
no preservative
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
KIT (c-KIT) is a proto-oncogene and a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). KIT was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT together with its ligand regulates growth and activation of a variety of hemopoietic and non-hemopoietic cells. Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Recently, deregulation of the KIT receptor TK by the prevalent activation loop mutation D816V has served as a focal point in therapeutic strategies aimed at curbing neoplastic mast cell growth. c-Kit is expressed in hematopoietic stem cells, germ cells, mast cells and gastrointestinal tract cajal cells. Upon binding of its ligand stem cell factor (SCF), c-kit dimerizes, resulting in receptor activation and autophosphorylation of various tyrosine residues including tyrosine 703 located on the cytoplasmic domain of the receptor. This modification allows docking of Grb2 and activation of the Ras/ERK signaling pathway. SCF/c-kit can activate multiple downstream signaling pathways including PI3K, PLC-gamma and JAK/STAT. c-kit receptor activation is essential for hematopoiesis, stem cell maintenance and gametogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: c-kit; ckit; Mast/stem cell growth factor receptor Kit; Proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; SCFR; Tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Gene Aliases: KIT; SCFR
UniProt ID: (Chicken) Q08156
Entrez Gene ID: (Chicken) 378783
activation of MAPK activity
ovarian follicle development
hematopoietic progenitor cell differentiation
myeloid progenitor cell differentiation
lymphoid progenitor cell differentiation
immature B cell differentiation
dendritic cell cytokine production
mast cell chemotaxis
glycosphingolipid metabolic process
inflammatory response
transmembrane receptor protein tyrosine kinase signaling pathway
multicellular organism development
spermatid development
positive regulation of cell proliferation
regulation of cell shape
male gonad development
response to radiation
positive regulation of gene expression
peptidyl-tyrosine phosphorylation
lamellipodium assembly
B cell differentiation
T cell differentiation
erythrocyte differentiation
melanocyte differentiation
positive regulation of cell migration
actin cytoskeleton reorganization
mast cell cytokine production
positive regulation of kinase activity
embryonic hemopoiesis
ectopic germ cell programmed cell death
intracellular signal transduction
hematopoietic stem cell migration
megakaryocyte development
Fc receptor signaling pathway
Kit signaling pathway
erythropoietin-mediated signaling pathway
positive regulation of tyrosine phosphorylation of STAT protein
negative regulation of programmed cell death
mast cell degranulation
positive regulation of MAP kinase activity
positive regulation of JAK-STAT cascade
protein autophosphorylation
digestive tract development
stem cell differentiation
detection of mechanical stimulus involved in sensory perception of sound
positive regulation of sequence-specific DNA binding transcription factor activity
mast cell differentiation
cellular response to thyroid hormone stimulus
melanocyte migration
melanocyte adhesion
positive regulation of vascular smooth muscle cell differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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