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Invitrogen

SOX4 Monoclonal Antibody (CL5634)

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SOX4 Monoclonal Antibody (CL5634)

Product Details

MA5-31423

Applications
Tested Dilution
Publications

Western Blot (WB)

-
View 1 publication 1 publication

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:1,000-1:2,500
-

Immunocytochemistry (ICC/IF)

2-10 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

CL5634

Immunogen

Synthetic peptide corresponding to Human SOX4
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2787059

Product Specific Information

Immunogen sequence: AGADPSDPLG LYEEEGAG

Highest antigen sequence indentity to the following orthologs: Rat - 78%, Mouse - 78%.

Target Information

SOX genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of SOX genes cluster at a minimum of 40 different loci that rapidly diverged in various animal lineages. At present 30 SOX genes have been identified, and members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: ecotropic viral integration site 16; SRY (sex determining region Y)-box 4; SRY-box 4; SRY-box containing gene 4; SRY-related HMG-box gene 4; Transcription factor SOX-4

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Gene Aliases: AA682046; CSS10; EVI16; Sox-4; SOX4

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UniProt ID: (Human) Q06945, (Mouse) Q06831

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Entrez Gene ID: (Human) 6659, (Rat) 364712, (Mouse) 20677

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding miRNA binding sequence-specific double-stranded DNA binding core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription coactivator activity protein heterodimerization activity nucleic acid binding transcription factor activity HMG box transcription factor
Process(es)
negative regulation of transcription from RNA polymerase II promoter pro-B cell differentiation mitral valve morphogenesis cardiac right ventricle morphogenesis atrial septum primum morphogenesis noradrenergic neuron differentiation regulation of transcription, DNA-templated nervous system development brain development heart development positive regulation of cell proliferation gene expression glial cell proliferation spinal cord development glial cell development neuron differentiation T cell differentiation endocrine pancreas development positive regulation of insulin secretion somatic stem cell population maintenance ascending aorta morphogenesis glucose homeostasis positive regulation of apoptotic process regulation of DNA damage response, signal transduction by p53 class mediator positive regulation of gamma-delta T cell differentiation negative regulation of myoblast differentiation positive regulation of myoblast differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter sympathetic nervous system development camera-type eye morphogenesis protein stabilization ventricular septum morphogenesis mesenchyme development neuroepithelial cell differentiation kidney morphogenesis hematopoietic stem cell homeostasis cellular response to glucose stimulus positive regulation of canonical Wnt signaling pathway skeletal system development response to hypoxia neural tube formation cardiac ventricle formation transcription from RNA polymerase II promoter DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest negative regulation of cell proliferation spinal cord motor neuron differentiation positive regulation of Wnt signaling pathway negative regulation of protein ubiquitination regulation of protein stability DNA damage response, detection of DNA damage positive regulation of translation negative regulation of protein export from nucleus canonical Wnt signaling pathway limb bud formation negative regulation of cell death positive regulation of N-terminal peptidyl-lysine acetylation transcription, DNA-templated
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