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Invitrogen
CXCR2 Monoclonal Antibody (GT547)
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FIGURE: 1 / 2
CXCR2 Antibody (MA5-31520) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of CXCR2 was performed in Mock and transfected 293T cells fixed in 4% paraformaldehyde at RT for 15 min. Green: CXCR2 Monoclonal Antibody (GT547) (Product # MA5-31520) diluted at 1:2000. Blue: Hoechst 33342 staining. Scale bar = 10 µm.
Product Details
MA5-31520
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
GT547
Immunogen
Recombinant protein encompassing a sequence within the N-terminus region of human CXCR2. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Keep as concentrated solution.
Predicted reactivity: Chimpanzee (100%).
Positive Control: 3xFlag-human CXCR2-transfected 293T.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
CXCR2 is a receptor for interleukin-8, which is a powerful neutrophil chemotactic factor. It is a member of the GPCR family. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to GRO/MGSA and NAP-2 also with a high affinity. It has been reported to be expressed in a wide variety of tissues. ESTs have been isolated from human placenta and thymus libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C Cmotif chemokine; C X C motif chemokine; C-X-C chemokine receptor type 2; CC motif chemokine; CCmotif chemokine; CD182; CD182 antigen; CDw128b; chemokine (CXC) receptor 2; CXC; CXC motif chemokine; CXC-R2; CXCR-2; CXCR2 gene for IL8 receptor type B; GRO/MGSA receptor; High affinity interleukin-8 receptor B; Il-8 receptor b; IL-8 receptor beta; IL-8 receptor type 2; IL-8R B; interleukin 8 receptor type 2; interleukin 8 receptor, beta; interleukin-8 receptor type B; unnamed protein product
Gene Aliases: CD182; CDw128b; CMKAR2; CXCR2; IL8R2; IL8RA; IL8RB; WHIMS2
UniProt ID: (Human) P25025
Entrez Gene ID: (Human) 3579
dendritic cell chemotaxis
chemotaxis
inflammatory response
immune response
cellular defense response
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
positive regulation of cell proliferation
calcium-mediated signaling
neutrophil chemotaxis
receptor internalization
interleukin-8-mediated signaling pathway
neutrophil activation
negative regulation of apoptotic process
chemokine-mediated signaling pathway
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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