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Invitrogen
Furin Recombinant Rabbit Monoclonal Antibody (JB35-53)
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Product Details
MA5-34677
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
JB35-53
Immunogen
Recombinant protein within Human Furin aa 261-310.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Control: HepG2, Hela, MCF-7, human liver tissue, human colon tissue, human placenta tissue, mouse brain tissue.
Target Information
Furin is a membrane-associated, calcium-dependent, serine protease that belongs to the subtilisin-like prohormone convertase (PC) family. Members of this family of cellular enzymes cleave most prohormones and neuropeptide precursors. Numerous other cellular proteins, some viral proteins, and bacterial toxins that are transported by the constitutive secretory pathway are also targeted for maturation by PCs. Furin and other PC family members share structural similarities which include a heterogeneous ~10 kDa amino-terminal proregion, a highly conserved ~55 kDa subtilisin-like catalytic domain, and carboxyl-terminal domain that is heterogeneous in length and sequence. These enzymes become catalytically active following proregion cleavage within the appropriate cellular compartment. Furin is the only known PC to possess a transmembrane domain. Cleavage of target proteins occurs at the carboxyl-terminus of the furin consensus sequence, RX(K/R)R. It has been shown that the acidic peptide sequence, C771PSDSEEDEG780, localizes furin to the trans-Golgi-network. Phosphorylation of serine residues within this region modulates intracellular routing of furin protein. An additional signaling domain includes the tetrapeptide sequence, Y759KGL762, which directs internalization from the cell surface.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: dibasic processing enzyme; Dibasic-processing enzyme; FES upstream region; Furin; furin, membrane associated receptor protein; PACE; Paired basic amino acid residue-cleaving enzyme; proprotein convertase subtilisin/kexin 3; proprotein convertase subtilisin/kexin type 3; subtilisin-like proprotein convertase 1; unnamed protein product
Gene Aliases: FUR; FURIN; PACE; PCSK3; SPC1
UniProt ID: (Human) P09958
Entrez Gene ID: (Human) 5045
protease binding
endopeptidase activity
serine-type endopeptidase activity
serine-type endopeptidase inhibitor activity
protein binding
heparin binding
peptidase activity
serine-type peptidase activity
hydrolase activity
peptide binding
metal ion binding
nerve growth factor binding
endopeptidase activator activity
heparan sulfate binding
blastocyst formation
negative regulation of inflammatory response to antigenic stimulus
signal peptide processing
proteolysis
transforming growth factor beta receptor signaling pathway
regulation of signal transduction
protein processing
peptide hormone processing
viral life cycle
viral translation
viral protein processing
extracellular matrix disassembly
extracellular matrix organization
collagen catabolic process
zymogen activation
regulation of cholesterol transport
negative regulation of low-density lipoprotein particle receptor catabolic process
nerve growth factor production
negative regulation of nerve growth factor production
negative regulation of transforming growth factor beta1 production
secretion by cell
plasma lipoprotein particle remodeling
regulation of protein catabolic process
peptide biosynthetic process
positive regulation of viral entry into host cell
viral entry into host cell
positive regulation of membrane protein ectodomain proteolysis
protein maturation
dibasic protein processing
zymogen inhibition
cytokine precursor processing
amyloid fibril formation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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