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Invitrogen

KDEL Monoclonal Antibody (2C1), PerCP

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KDEL Monoclonal Antibody (2C1), PerCP

Product Details

MA5-45871

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:25
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

2C1

Immunogen

KDEL peptide (C-AVKDEL -COOH) conjugated at the N-terminal to Bovine Serum Albumin (BSA)
3D Epitope / Immunogen

Conjugate

PerCP PerCP PerCP

Excitation/Emission Max

482/675 nm View spectra spectra

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

95.64mM phosphate/2.48mM MES, pH 7.4, with 0.5M EDTA

Contains

no preservative

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2932325

Product Specific Information

A 1:1,000 dilution of MA5-45871 was sufficient for detection of KDEL in 10 µg of HeLa cell lysates by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.|Detects KDEL tagged proteins.

Target Information

The sequence Lys-Asp-Glu-Leu (KDEL) or a closely related sequence, is present at the carboxy-terminus of soluble endoplasmic reticulum (ER) resident proteins and some membrane proteins. 78 and 94 kDa glucose regulated proteins, GRP78 and GRP94 respectively, and protein disulfide isomerase (PDI) all share the C-terminal KDEL sequence. The presence of carboxy-terminal KDEL appears to be necessary for ER retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 78 kDa glucose-regulated protein; 94 kDa glucose-regulated protein; binding-immunoglobulin protein; BiP; chaperone; endoplasmic reticulum lumenal Ca(2+)-binding protein grp78; endoplasmic reticulum resident protein 99; endoplasmic reticulum transmembrane protein precursor; endoplasmin; endothelial cell (HBMEC) glycoprotein; epididymis luminal protein 35; epididymis secretory sperm binding protein Li 125m; epididymis secretory sperm binding protein Li 89n; glucose regulated protein, 78 kDa; glucose-regulated protein (grp78); glucose-regulated protein 78; glucose-regulated protein, 78kDa; GRP-78; GRP-94; GRP94; heat shock 70 kDa protein 5; heat shock 70kD protein 5; heat shock 70kD protein 5 (glucose-regulated protein, 78kD); heat shock 70kDa protein 5 (glucose-regulated protein); heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); heat shock protein 5; heat shock protein 70 family protein 5; heat shock protein 90 kDa beta member 1; heat shock protein 90, beta, member 1; heat shock protein 90kDa beta (Grp94), member 1; heat shock protein 90kDa beta family member 1; heat shock protein family A member 5; heat shock protein family C member 4; HSP70 family protein 5; immunoglobulin heavy chain binding protein; immunoglobulin heavy chain-binding protein; KDEL; KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1; KDEL (Lys-Asp-Glu-Leu) receptor; KDELR1; KDEL endoplasmic reticulum protein retention receptor 1; KDEL receptor 1; Lys-Asp-Glu-Leu; polymorphic tumor rejection antigen 1; polymorphic tumor rejection antigen precursor; preimmunoglobulin heavy chain binding protein; putative MAPK-activating protein PM23; RP23-446N16.1; steroidogenesis-activator polypeptide; stress-inducible tumor rejection antigen gp96; transforming growth factor alpha regulated gene 2; tumor rejection antigen (gp96) 1; tumor rejection antigen 1; tumor rejection antigen gp96; unnamed protein product; XAP-1 antigen

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Gene Aliases: 8030486F04Rik; baffled; BIP; D2Wsu141e; D2Wsu17e; ECGP; endoplasmin; ERD2; ERD2.1; ERp99; GP96; GRP 78; GRP78; GRP94; HDEL; HEL-S-125m; HEL-S-89n; HEL35; Hsce70; mBiP; PM23; SEZ-7; Sez7; TA-3; Targ2; Tra-1; TRA1

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UniProt ID: (Human) P14625, (Human) P11021, (Mouse) P08113, (Rat) Q66HD0, (Rat) P06761, (Mouse) P20029, (Human) P24390, (Mouse) Q99JH8, (Rat) Q569A6

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Entrez Gene ID: (Human) 7184, (Human) 3309, (Mouse) 22027, (Rat) 362862, (Rat) 25617, (Mouse) 14828, (Human) 10945, (Mouse) 68137, (Rat) 361577

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Function(s)
RNA binding protein phosphatase inhibitor activity calcium ion binding protein binding ATP binding ATPase activity protein phosphatase binding AP-3 adaptor complex binding protein binding involved in protein folding low-density lipoprotein particle receptor binding ATP-dependent protein folding chaperone enzyme binding protein domain specific binding protein serine/threonine kinase inhibitor activity heat shock protein binding ubiquitin protein ligase binding ribosome binding cadherin binding chaperone binding misfolded protein binding protein sequestering activity KDEL sequence binding ER retention sequence binding
Process(es)
luteolysis ER overload response response to hormone positive regulation of neuron projection development cerebellum structural organization cerebellar Purkinje cell layer development neuron differentiation positive regulation of cell migration negative regulation of transforming growth factor beta receptor signaling pathway endoplasmic reticulum unfolded protein response posttranslational protein targeting to membrane, translocation negative regulation of protein complex assembly positive regulation of protein ubiquitination response to endoplasmic reticulum stress maintenance of protein localization in endoplasmic reticulum IRE1-mediated unfolded protein response ERAD pathway protein refolding cellular response to glucose starvation response to cocaine negative regulation of apoptotic process positive regulation of protein catabolic process neuron apoptotic process cellular response to antibiotic cellular response to calcium ion cellular response to manganese ion cellular response to cAMP cellular response to interleukin-4 cellular response to xenobiotic stimulus cellular response to gamma radiation stress response to metal ion regulation of IRE1-mediated unfolded protein response negative regulation of IRE1-mediated unfolded protein response negative regulation of PERK-mediated unfolded protein response response to methamphetamine hydrochloride cellular response to nerve growth factor stimulus protein retention in ER lumen retrograde vesicle-mediated transport, Golgi to ER T cell differentiation T cell apoptotic process response to hypoxia protein folding insulin processing positive regulation of Wnt signaling pathway retrograde protein transport, ER to cytosol actin rod assembly positive regulation of toll-like receptor signaling pathway cellular response to ATP protein localization to plasma membrane substantia nigra development protein folding in endoplasmic reticulum positive regulation of transcription from RNA polymerase II promoter regulation of protein folding in endoplasmic reticulum regulation of ATF6-mediated unfolded protein response regulation of PERK-mediated unfolded protein response translational initiation PERK-mediated unfolded protein response positive regulation of embryonic development protein transport
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