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Invitrogen
F4/80 Monoclonal Antibody (BM8)
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FIGURE: 1 / 61
F4/80 Antibody (MF48000) in IHC (P)
Cell reports 2021 -
Figure 5. The composition of tumor-associated macrophages varies with treatment modality (A) Immunohistochemical staining with F4/80 shows a dramatic increase in macrophages with radiation therapy. Student's t test. n = 3 animals per treatment group. Rsssssesults are expressed as mean +- SEM. **p < 0.01. Field: 3,190 x 1,974 mum. Scale bar: 200 muM. (B) UMAP plots of myeloid cells from treated tumors show h... View More
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.jpg?time=20240507?time=20240507 "F4/80 Antibody (MF48000) in IHC")
Product Details
MF48000
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Published species
Human,
Mouse
Host/Isotype
Rat
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
BM8
Immunogen
mouse F4/80 which is a macrophage-restricted cell surface glycoprotein.
Conjugate
Form
Liquid
Purification
purified
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
F4/80 antigen is a 160 kDa cell surface glycoprotein that is a member of the EGF TM7 family of proteins and shares 68% overall amino acid identity with human EGF module containing mucin like hormone receptor 1 (EMR1). Expression of F4/80 is heterogeneous and is reported to vary during macrophage maturation and activation. The F4/80 antigen is expressed on a wide range of mature tissue macrophages including Kupffer cells, Langerhans, microglia, macrophages located in the gut lamina propria, peritoneal cavity, lung, thymus, bone marrow stroma and macrophages in the red pulp of the spleen. F4/80 expression has also been reported on a subpopulation of dendritic cells but is absent from macrophages located in T cell areas of the spleen and lymph node. The ligands and biological functions of the F4/80 antigen have not yet been determined but recent studies suggest a role for F4/80 in the generation of efferent CD8+ve regulatory T cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Adhesion G protein-coupled receptor E1; Cell surface glycoprotein F4/80; EGF-like module containing, mucin-like, hormone receptor-like sequence 1; EGF-like module receptor 1; EGF-like module-containing mucin-like hormone receptor-like 1; EMR1 hormone receptor; lymphocyte antigen 71
Gene Aliases: Adgre1; DD7A5-7; EGF-TM7; Emr1; F4/80; Gpf480; Ly71; TM7LN3
UniProt ID: (Mouse) Q61549
Entrez Gene ID: (Mouse) 13733
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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