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Invitrogen
ERp57 Polyclonal Antibody
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Product Details
PA1-31316
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide with sequence C-EEKPKKKKKAQEDL, from the C Terminus.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: The peptide used to generate this antibody is available for purchase (GTX17012-PEP)..
Target Information
This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 58 kDa glucose-regulated protein; 58 kDa microsomal protein; Disulfide isomerase ER-60; endoplasmic reticulum P58; endoplasmic reticulum protein; Endoplasmic reticulum resident protein 57; Endoplasmic reticulum resident protein 60; epididymis secretory protein Li 269; epididymis secretory sperm binding protein Li 93n; ER p57; ER protein 57; ER protein 60; ERp 57; glucose regulated protein, 58 kDa; glucose regulated protein, 58kDa; GRP 57; GRP 58; p58; PDIA 3; phospholipase C, alpha; phospholipase C-alpha; PI PLC; protein disulfide isomerase-associated 3; Protein disulfide-isomerase A3; unnamed protein product
Gene Aliases: 58kDa; ER60; Erp; ERP57; ERP60; ERp61; GRP57; GRP58; HEL-S-269; HEL-S-93n; HsT17083; P58; PDI; PDI-Q2; PDIA3; PI-PLC; PLC[a]; Plca
UniProt ID: (Human) P30101, (Mouse) P27773
Entrez Gene ID: (Human) 2923, (Mouse) 14827
RNA binding
protein disulfide isomerase activity
cysteine-type endopeptidase activity
phospholipase C activity
protein binding
protein disulfide oxidoreductase activity
disulfide oxidoreductase activity
isomerase activity
identical protein binding
lncRNA binding
peptidase activity
protein-disulfide reductase (glutathione) activity
MHC class I protein binding
poly(A) RNA binding
chaperone
adaptive immune response
immune system process
peptide antigen assembly with MHC class I protein complex
protein folding
protein folding in endoplasmic reticulum
response to endoplasmic reticulum stress
platelet aggregation
extrinsic apoptotic signaling pathway
cellular response to interleukin-7
positive regulation of extrinsic apoptotic signaling pathway
proteolysis
cell redox homeostasis
oxidation-reduction process
cellular response to vitamin D
positive regulation of protein folding
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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