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Invitrogen
ARHGEF1 Polyclonal Antibody
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Product Details
PA5-101844
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ARHGEF1(Accession Q92888), corresponding to amino acid residues R161-D211.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total ARHGEF1.
Target Information
The Ras superfamily of GTPases, which can be subdivided into the Ras, Rho/Rac, Sar, Rab, ARF and Ran subfamilies, controls multiple aspects of cell function, including cytoskeletal rearrangement, nuclear signaling and cell growth. The Ras superfamily of GTPases function as regulated switches that toggle between a biologically active GTP-bound and an inactive GDP-bound form. This activation is catalyzed by guanine nucleotide exchange factors (GEFs). The Dbl-related proteins are a large family of structurally related molecules that have a common ability to catalyze GEF activity for specific members of the Ras family. Dbl-related proteins include FGD1, Lsc, RhoGEF p115, Lfc, Lbc and Brx. Lsc, Lbc and Lfc share sequence homology and show exchange activity toward Rho family GTPases. RhoGEF p115 catalyzes GEF activity for Rho but not Rac, Cdc42 or Ras GTPases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 115 kDa guanine nucleotide exchange factor; 115-kD protein; Lbc's second cousin; Lsc homolog; lymphoid blast crisis like 2; Lymphoid blast crisis-like 2; p115-RhoGEF; p115RhoGEF; Rho guanine nucleotide exchange factor (GEF) 1; Rho guanine nucleotide exchange factor 1; Sub1.5
Gene Aliases: ARHGEF1; GEF1; IMD62; LBCL2; LSC; P115-RHOGEF; SUB1.5
UniProt ID: (Human) Q92888, (Mouse) Q61210
Entrez Gene ID: (Human) 9138, (Mouse) 16801, (Rat) 60323
G-protein coupled receptor signaling pathway
Rho protein signal transduction
regulation of small GTPase mediated signal transduction
Rho-activating G protein-coupled receptor signaling pathway
regulation of Rho protein signal transduction
termination of G-protein coupled receptor signaling pathway
negative regulation of cell death
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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