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Invitrogen

Phospho-SRC3 (Thr24) Polyclonal Antibody

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Phospho-SRC3 (Thr24) Polyclonal Antibody

Product Details

PA5-104658

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human NCOA3(Accession Q9Y6Q9), corresponding to amino acid residues around phosphorylated Thr24.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2816133

Product Specific Information

Antibody detects endogenous levels of SRC3 only when phosphorylated at Thr24.

Target Information

AIB1-AC3 recognizes AIB1, a member of the SRC-1 family of nuclear receptor coactivators with an apparent molecular weight of 160kDa. The AIB1 gene has been mapped to region 20q12 and has been shown to be amplified in breast tumors and pancreatic cancer cell lines. AIB1 interacts in a ligand-dependent fashion with the estrogen receptor to enhance estrogen-dependent transcriptional gene activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ACTR; AIB-1; Amplified in breast cancer 1 protein; amplified in breast cancer-1 protein homolog; bHLHe42; CBP-interacting protein; Class E basic helix-loop-helix protein 42; MGC141848; NCoA-3; nuclear hormone receptor coactivator protein; nuclear receptor co-activator; Nuclear receptor coactivator 3; OTTHUMP00000031716; pCIP; RAC-3; Receptor-associated coactivator 3; RP5-1049G16.3; SRC-3; Steroid receptor coactivator protein 3; Thyroid hormone receptor activator molecule 1; TRAM-1; unnamed protein product

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Gene Aliases: 2010305B15Rik; ACTR; AIB-1; AIB1; AW321064; BHLHE42; CAGH16; CTG26; KAT13B; NCOA3; p/Cip; pCIP; RAC3; SRC-3; SRC3; TNRC14; TNRC16; TRAM-1; TRAM1

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UniProt ID: (Human) Q9Y6Q9

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Entrez Gene ID: (Human) 8202, (Mouse) 17979, (Rat) 84584

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Function(s)
RNA polymerase II core binding transcription cofactor activity transcription coactivator activity histone acetyltransferase activity protein binding transferase activity transferase activity, transferring acyl groups ligand-dependent nuclear receptor binding thyroid hormone receptor binding protein dimerization activity peptide-lysine-N-acetyltransferase activity disordered domain specific binding RNA polymerase II regulatory region DNA binding chromatin binding signal transducer activity estrogen receptor binding ligand-dependent nuclear receptor transcription coactivator activity protein complex binding nuclear hormone receptor binding peroxisome proliferator activated receptor binding protein N-terminus binding androgen receptor binding histone modifying enzyme
Process(es)
chromatin remodeling regulation of transcription, DNA-templated cellular response to hormone stimulus cell dedifferentiation positive regulation of keratinocyte differentiation positive regulation of transcription from RNA polymerase II promoter retinoic acid receptor signaling pathway vitamin D receptor signaling pathway cellular response to estradiol stimulus nucleus-associated proteasomal ubiquitin-dependent protein catabolic process positive regulation of stem cell population maintenance regulation of stem cell division transcription, DNA-templated signal transduction positive regulation of gene expression histone acetylation positive regulation of cell growth positive regulation of intracellular steroid hormone receptor signaling pathway positive regulation of intracellular estrogen receptor signaling pathway multicellular organism growth negative regulation of apoptotic process developmental growth positive regulation of sequence-specific DNA binding transcription factor activity vagina development labyrinthine layer morphogenesis mammary gland branching involved in thelarche regulation of RNA biosynthetic process male gonad development
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