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Invitrogen

Phospho-PDGF Receptor beta (Tyr1021) Polyclonal Antibody

View all (101) PDGFRB (CD140b) antibodies

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Phospho-PDGF Receptor beta (Tyr1021) Polyclonal Antibody

Product Details

PA5-117387

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Carrier-protein conjugated synthetic peptide surrounding phospho Tyr1021 of human PDGF Receptor beta. The exact sequence is proprietary.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.63 mg/mL

Amount

63 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 1% BSA, 20% glycerol

Contains

0.025% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2902017

Product Specific Information

Centrifuge briefly prior to opening.

Target Information

PDGFRB is a receptor tyrosine kinase and has been implicated in atherogenesis and in cell transformation by the SIS oncogene. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. The gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses PDGFRB (CD140b) to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Activated tyrosine kinase PDGFRB; Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; CD140b; CD140b antigen; NDEL1-PDGFRB; PDGF beta chain; PDGF Receptor beta; PDGF-R-beta; PDGFR-1; PDGFR-beta; Platelet-derived growth factor receptor 1; Platelet-derived growth factor receptor beta; platelet-derived growth factor receptor beta variant 1; platelet-derived growth factor receptor, beta polypeptide; unnamed protein product

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Gene Aliases: AI528809; CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD; PDGFR; PDGFR-1; PDGFR1; PDGFRB; PENTT

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UniProt ID: (Human) P09619, (Mouse) P05622

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Entrez Gene ID: (Human) 5159, (Mouse) 18596

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Function(s)
nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity platelet activating factor receptor activity platelet-derived growth factor-activated receptor activity platelet-derived growth factor beta-receptor activity GTPase activator activity receptor binding platelet-derived growth factor receptor binding protein binding ATP binding kinase activity transferase activity enzyme binding protein kinase binding vascular endothelial growth factor binding platelet-derived growth factor binding phospholipase C activator activity signal transducer activity transferase activity, transferring phosphorus-containing groups phosphatidylinositol 3-kinase binding transmembrane signal receptor
Process(es)
angiogenesis chemotaxis signal transduction transmembrane receptor protein tyrosine kinase signaling pathway G-protein coupled receptor signaling pathway positive regulation of cell proliferation smooth muscle adaptation positive regulation of smooth muscle cell migration cell migration peptidyl-tyrosine phosphorylation positive regulation of cell migration regulation of actin cytoskeleton organization cell migration involved in vasculogenesis platelet-derived growth factor receptor-beta signaling pathway positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway aorta morphogenesis cellular response to platelet-derived growth factor stimulus positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway positive regulation of MAP kinase activity positive regulation of mitotic nuclear division protein autophosphorylation platelet-derived growth factor receptor signaling pathway positive regulation of smooth muscle cell proliferation positive regulation of calcium-mediated signaling positive regulation of chemotaxis positive regulation of protein kinase B signaling cardiac myofibril assembly cell chemotaxis cell migration involved in coronary angiogenesis retina vasculature development in camera-type eye positive regulation of ERK1 and ERK2 cascade smooth muscle cell chemotaxis metanephric glomerular mesangial cell proliferation involved in metanephros development metanephric glomerular capillary formation positive regulation of calcium ion import positive regulation of reactive oxygen species metabolic process positive regulation of DNA biosynthetic process in utero embryonic development kidney development tissue homeostasis glycosaminoglycan biosynthetic process protein phosphorylation nitrogen compound metabolic process multicellular organism development positive regulation of phospholipase C activity positive regulation of phosphatidylinositol 3-kinase signaling phosphorylation hemopoiesis adrenal gland development positive regulation of phosphoprotein phosphatase activity positive regulation of collagen biosynthetic process intracellular signal transduction metanephric mesenchymal cell migration negative regulation of apoptotic process positive regulation of phosphatidylinositol 3-kinase activity phosphatidylinositol metabolic process phosphatidylinositol-mediated signaling skeletal system morphogenesis smooth muscle tissue development regulation of peptidyl-tyrosine phosphorylation cardiac vascular smooth muscle cell differentiation
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