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Invitrogen
Phospho-CDC2 (Thr14) Polyclonal Antibody
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FIGURE: 1 / 2
Phospho-CDC2 (Thr14) Antibody (PA5-117399) in WB
Western blot analysis of Phospho-CDC2 (Thr14) in Untreated (–) and treated (+) HeLa whole cell extracts (30 µg). Samples were separated with 12% SDS-PAGE and incubated in Phospho-CDC2 (Thr14) polyclonal antibody (Product # PA5-117399) using a dilution of 1:500, followed by HRP-conjugated anti-rabbit IgG.
Product Details
PA5-117399
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Carrier-protein conjugated synthetic peptide surrounding phospho Thr14 of human CDC2. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.92 mg/mL
Amount
92 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol, 1% BSA
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Centrifuge briefly prior to opening.
Target Information
CDK1 or Cell Division Control protein 1 is essential for the completion of START, the controlling event in the cell cycle that is required to initiate mitosis. CDK1 is a catalytic subunit of a protein kinase complex, called the M-Phase Promoting Factor that induces entry into mitosis and is universal among eukaryotes. Phosphorylation of Bcl-2 in G2/M phase-arrested cells following photodynamic therapy with hypericin involves a CDK1-mediated signal and delays the onset of apoptosis. Therapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancer has also been demonstrated.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ABL1; CDK1; cell cycle controller CDC2; cell cycle p34 CDC2 kinase protein; Cell division control protein 2 homolog; cell division cycle 2 homolog A; cell division cycle 2, G1 to S and G2 to M; cell division cycle control protein 2a; Cell division protein kinase 1; Cyclin-dependent kinase 1; DKFZp686L20222; KCIP-1; MGC111195; MGC53829; OTTHUMP00000019660; P34 CDK1; P34 MGC111195; p34 protein kinase; Protein 1054; unnamed protein product
Gene Aliases:
CDC2; CDC28A; Cdc2a; CDK1; CDKN1; p34
UniProt ID: (Human) P06493, (Mouse) P11440
Entrez Gene ID: (Human) 983, (Mouse) 12534
nucleotide binding
virus receptor activity
chromatin binding
protein kinase activity
protein serine/threonine kinase activity
cyclin-dependent protein serine/threonine kinase activity
protein binding
ATP binding
RNA polymerase II carboxy-terminal domain kinase activity
kinase activity
transferase activity
cyclin binding
Hsp70 protein binding
histone kinase activity
cyclin-dependent protein kinase activity
protein serine kinase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
G1/S transition of mitotic cell cycle
G2/M transition of mitotic cell cycle
microtubule cytoskeleton organization
DNA replication
DNA repair
chromatin remodeling
regulation of transcription from RNA polymerase II promoter
apoptotic process
cellular response to DNA damage stimulus
nuclear envelope organization
mitotic nuclear envelope disassembly
mitotic G2 DNA damage checkpoint
centrosome cycle
pronuclear fusion
response to toxic substance
positive regulation of gene expression
negative regulation of gene expression
positive regulation of G2/M transition of mitotic cell cycle
regulation of Schwann cell differentiation
response to amine
response to activity
cell migration
protein deubiquitination
peptidyl-threonine phosphorylation
chromosome condensation
epithelial cell differentiation
protein localization to kinetochore
positive regulation of protein import into nucleus
response to hydrogen peroxide
regulation of circadian rhythm
negative regulation of apoptotic process
mitotic cell cycle phase transition
response to ethanol
positive regulation of DNA replication
regulation of embryonic development
thymidine biosynthetic process
response to cadmium ion
response to copper ion
viral entry into host cell
microtubule polymerization
fibroblast proliferation
rhythmic process
response to axon injury
cell division
ventricular cardiac muscle cell development
positive regulation of cardiac muscle cell proliferation
cilium disassembly
positive regulation of mitotic sister chromatid segregation
protein-containing complex assembly
cellular response to hydrogen peroxide
ERK1 and ERK2 cascade
Golgi disassembly
DNA strand resection involved in replication fork processing
positive regulation of protein localization to nucleus
regulation of mitotic attachment of spindle microtubules to kinetochore
microtubule cytoskeleton organization involved in mitosis
DNA synthesis involved in mitotic DNA replication
positive regulation of mitochondrial ATP synthesis coupled electron transport
protein localization to site of double-strand break
mitotic DNA-dependent DNA replication
protein complex assembly
protein phosphorylation
cell cycle
mitotic nuclear division
cell aging
response to organonitrogen compound
phosphorylation
histone phosphorylation
peptidyl-serine phosphorylation
organ regeneration
positive regulation of protein import into nucleus, translocation
positive regulation of mitotic cell cycle
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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