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Invitrogen
ATP7B Polyclonal Antibody
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FIGURE: 1 / 1
ATP7B Antibody (PA5-120938) in WB
Western blot analysis of ATP7B in rat liver. Samples were incubated with ATP7B Polyclonal antibody (Product # PA5-120938) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.
Product Details
PA5-120938
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1251-1351 of human ATP7B (NP_0012301111)
Conjugate
Form
Liquid
Concentration
1.73 mg/mL
Amount
173 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive test controls include: BT-474, HL-60, Mouse liver. The target is usually found in the following locations: Cytoplasm, Golgi apparatus, Golgi apparatus membrane, Mitochondrion, Multi-pass membrane protein, Multi-pass membrane protein, trans-Golgi network membrane.
Immunogen sequence: SSVSVVLSSL QLKCYKKPDL ERYEAQAHGH MKPLTASQVS VHIGMDDRWR DSPRATPWDQ VSYVSQVSLS SLTSDKPSRH SAAADDDGDK WSLLLNGRDE E
Target Information
This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATPase, Cu(2+)- transporting, beta polypeptide; ATPase, Cu++ transporting, beta polypeptide; ATPase, Cu++ transporting, beta polypeptide (same as Wilson disease); Copper pump 2; copper transport protein; mutant protein; Copper-transporting ATPase 2; copper-transporting protein ATP7B; ORF; PINA gene, promoter; pineal night-specific ATPase; putative; RP11-327P2.1; RP11-327P2.3; unnamed protein product; Wilson disease-associated protein; wilson disease-associated protein homolog
Gene Aliases: ATP7B; Hts; PINA; PWD; WC1; WD; WND
UniProt ID: (Human) P35670
Entrez Gene ID: (Human) 540, (Rat) 24218
nucleotide binding
copper ion transmembrane transporter activity
copper ion binding
protein binding
ATP binding
ATPase activity
cation-transporting ATPase activity
copper-transporting ATPase activity
metal ion binding
P-type monovalent copper transporter activity
copper-exporting ATPase activity
zinc ion binding
primary active transporter
ion transport
cation transport
copper ion transport
cellular copper ion homeostasis
cellular zinc ion homeostasis
lactation
copper ion import
ion transmembrane transport
response to copper ion
sequestering of calcium ion
protein maturation
establishment of localization in cell
copper ion export
viral translational frameshifting
drug transmembrane export
circadian rhythm
metabolic process
response to zinc ion
intracellular copper ion transport
metal ion transport
copper ion transmembrane transport
response to cAMP
cation transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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