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Invitrogen
Phospho-Ezrin (Tyr353) Polyclonal Antibody
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Product Details
PA5-17683
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding pTyr353 of human Ezrin
Conjugate
Form
Liquid
Concentration
71 µg/mL
Amount
7.1 µg
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
This antibody is not cross-reactive with phosphorylated Moesin or Radixin.
Target Information
The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cytovillin; cytovillin 2; DKFZp762H157; epididymis secretory protein Li 105; EZRI; Ezrin; FLJ26216; MGC1584; p81; unnamed protein product; villin 2 (ezrin); villin 2; CVL; villin 2; kinase substrate; Villin-2
Gene Aliases: CVIL; CVL; EZR; HEL-S-105; VIL2
UniProt ID: (Human) P15311
Entrez Gene ID: (Human) 7430
RNA binding
actin binding
protein binding
microtubule binding
cytoskeletal protein binding
protein domain specific binding
protein kinase A catalytic subunit binding
protein kinase A regulatory subunit binding
identical protein binding
S100 protein binding
cadherin binding
cell adhesion molecule binding
actin filament binding
protein kinase A binding
ATPase binding
disordered domain specific binding
negative regulation of transcription from RNA polymerase II promoter
intestinal D-glucose absorption
sphingosine-1-phosphate signaling pathway
leukocyte cell-cell adhesion
regulation of cell shape
positive regulation of gene expression
protein kinase A signaling
gland morphogenesis
membrane to membrane docking
microvillus assembly
actin cytoskeleton organization
astral microtubule organization
protein complex localization
receptor internalization
regulation of microvillus length
negative regulation of interleukin-2 production
regulation of actin cytoskeleton organization
establishment or maintenance of apical/basal cell polarity
positive regulation of multicellular organism growth
cortical microtubule organization
establishment of epithelial cell apical/basal polarity
positive regulation of protein catabolic process
filopodium assembly
negative regulation of T cell receptor signaling pathway
actin filament bundle assembly
establishment of centrosome localization
establishment of endothelial barrier
negative regulation of ERK1 and ERK2 cascade
cellular response to cAMP
protein localization to plasma membrane
protein localization to cell cortex
postsynaptic actin cytoskeleton organization
regulation of NIK/NF-kappaB signaling
regulation of organelle assembly
terminal web assembly
positive regulation of protein localization to early endosome
positive regulation of protein localization to plasma membrane
negative regulation of p38MAPK cascade
positive regulation of early endosome to late endosome transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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