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Invitrogen
L3MBTL1 Polyclonal Antibody
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Product Details
PA5-21518
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
C. elegans,
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human L3MBTL1. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: HeLaS3, human L3MBTL-transfected 293T.
Predicted reactivity: Mouse (88%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
L3MBTL1 is the homolog of a protein identified in Drosophila as a suppressor of malignant transformation of neuroblasts and ganglion-mother cells in the optic centers of the brain. L3MBTL1 is localized to condensed chromosomes in mitotic cells and overexpression of this protein in a glioma cell line results in improper nuclear segregation and cytokinesis producing multinucleated cells. L3MBTL1 represents a polycomb group gene the encoded protein functions to regulate gene activity, likely via chromatin modification. Polycomb group protein specifically recognizes and binds mono- and dimethyllysine residues on target proteins, thereby acting as a reader of a network of post-translational modifications. Alternatively spliced transcript variants encoding different isoforms of the L3MBTL1 gene have been identified.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: H-l(3)mbt; L(3)mbt protein homolog; l(3)mbt-like 1; L3MBTL1; L3MBTL1, histone methyl-lysine binding protein; lethal (3) malignant brain tumor l(3); Lethal(3)malignant brain tumor-like protein 1; RP1-138B7.1; unnamed protein product
Gene Aliases: dJ138B7.3; H-L(3)MBT; KIAA0681; L3MBT; L3MBTL; L3MBTL1; ZC2HC3
UniProt ID: (Human) Q9Y468
Entrez Gene ID: (Human) 26013
chromatin organization
regulation of transcription, DNA-templated
regulation of mitotic nuclear division
hemopoiesis
heterochromatin assembly
regulation of megakaryocyte differentiation
negative regulation of transcription, DNA-templated
regulation of cell cycle
regulation of macromolecule metabolic process
regulation of primary metabolic process
constitutive heterochromatin formation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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