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Invitrogen
NR0B1 Polyclonal Antibody
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FIGURE: 1 / 2
NR0B1 Antibody (PA5-21645) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of NR0B1 was performed in HeLa cells fixed in 4% paraformaldehyde at RT for 15 min. Green: NR0B1 Polyclonal Antibody (Product # PA5-21645) diluted at 1:200. Red: phalloidin, a cytoskeleton marker. Scale bar = 10 µm.
Product Details
PA5-21645
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human NR0B1. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Amount
40 µg
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Predicted reactivity: Rhesus Monkey (95%), Chimpanzee (99%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes a protein that contains a DNA-binding domain. The encoded protein acts as a dominant-negative regulator of transcription which is mediated by the retinoic acid receptor. This protein also functions as an anti-testis gene by acting antagonistically to Sry. Mutations in this gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DAX 1; DSS-AHC critical region on the X chromosome protein 1; nuclear hormone receptor; nuclear hormone receptor/negative regulator of retinoic acid receptor-mediated transcription; Nuclear receptor DAX-1; Nuclear receptor subfamily 0 group B member 1; R0B1
Gene Aliases: AHC; AHCH; AHX; DAX-1; DAX1; DSS; GTD; HHG; NR0B1; NROB1; SRXY2
UniProt ID: (Human) P51843
Entrez Gene ID: (Human) 190
nucleic acid binding
transcription corepressor activity
RNA binding
protein binding
ligand-dependent nuclear receptor binding
protein domain specific binding
DNA hairpin binding
protein homodimerization activity
AF-2 domain binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
negative regulation of transcription from RNA polymerase II promoter
developmental process involved in reproduction
spermatogenesis
sex determination
protein localization
gonad development
male gonad development
negative regulation of steroid biosynthetic process
hypothalamus development
pituitary gland development
male sex determination
adrenal gland development
negative regulation of intracellular steroid hormone receptor signaling pathway
Leydig cell differentiation
response to immobilization stress
endodermal cell differentiation
negative regulation of gluconeogenesis
negative regulation of transcription, DNA-templated
Sertoli cell differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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