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Invitrogen
UNC13B Polyclonal Antibody
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FIGURE: 1 / 3
UNC13B Antibody (PA5-22159) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of UNC13B was performed in DIV9 rat E18 primary cortical neuron cells fixed in 4% paraformaldehyde at RT for 15 min. Green: UNC13B Polyclonal Antibody (Product # PA5-22159) diluted at 1:500. Red: beta Tubulin 3/ Tuj1, stained by beta Tubulin 3/ Tuj1 antibody. Blue: Fluoroshield with DAPI.
Product Details
PA5-22159
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human UNC13B. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: 293T, HeLa.
Predicted reactivity: Mouse (98%), Rat (98%), Bovine (97%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: contains C2 domains; homolog of rat Munc13 (diacylglycerol-binding); munc13; Munc13-2; Protein unc-13 homolog B; unc-13-like; unnamed protein product
Gene Aliases: MUNC13; Munc13-2; UNC13; UNC13B; Unc13h2
UniProt ID: (Human) O14795, (Rat) Q62769
Entrez Gene ID: (Human) 10497, (Rat) 64830
chemical synaptic transmission
neuromuscular junction development
positive regulation of synaptic vesicle priming
synaptic vesicle docking
synaptic vesicle priming
synaptic transmission, glutamatergic
intracellular signal transduction
regulation of short-term neuronal synaptic plasticity
innervation
positive regulation of inhibitory postsynaptic potential
exocytosis
positive regulation of apoptotic process
positive regulation of protein secretion
acrosomal vesicle exocytosis
dense core granule priming
cellular response to glucose stimulus
neuronal dense core vesicle exocytosis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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