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Invitrogen

Calcineurin A Polyclonal Antibody

View all (33) Calcineurin A antibodies

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Product Details

PA5-29209

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:10,000
-

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-

ChIP assay (ChIP)

Assay-Dependent
-
Product Specifications

Species Reactivity

Amphibian, Human, Mouse, Rodent, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the center region of human Calcineurin A. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.98 mg/mL

Amount

98 µg

Purification

Antigen affinity chromatography

Storage buffer

0.1M tris glycine, pH 7, with 20% glycerol

Contains

0.01% thimerosal

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2546685

Product Specific Information

Recommended positive controls: Neuro 2A, C8D30, NIH-3T3, Raw264.7, C2C12, Molt-4, U87-MG, SK-N-SH, SK-N-AS, IMR32, JC, BCL-1, rat brain, human Calcineurin A-transfected 293T.

Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (90%), Xenopus laevis (98%), Dog (100%), Pig (99%), Rabbit (100%), Rhesus Monkey (100%), Bovine (99%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results in multiple transcript variants encoding two different isoforms.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Calcineurin A alpha; Calcineurin A1; calcineurin catalytic subunit; Calcineurin subunit A alpha; CalcineurinA; Calmodulin-dependent calcineurin A subunit alpha isoform; CALNA 1; CAM-PRP catalytic subunit; CCN 1; CNA alpha; PP2B alpha 1; PP2BA alpha; PP2CB; protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform; Protein phosphatase 3 catalytic subunit alpha; protein phosphatase 3 catalytic subunit alpha isozyme; protein phosphatase 3, catalytic subunit, alpha isoform; protein phosphatase-2Ba; Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; unnamed protein product

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Gene Aliases: 2900074D19Rik; ACCIID; CALN; CALNA; CALNA1; CCN1; CN; CNA; CNA1; DEE91; IECEE; IECEE1; PPP2B; PPP3CA

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UniProt ID: (Human) Q08209, (Mouse) P63328, (Rat) P63329

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Entrez Gene ID: (Human) 5530, (Mouse) 19055, (Rat) 24674

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Function(s)
phosphoprotein phosphatase activity protein serine/threonine phosphatase activity calcium ion binding protein binding calmodulin binding hydrolase activity enzyme binding calmodulin-dependent protein phosphatase activity metal ion binding protein dimerization activity ATPase binding calcium-dependent protein serine/threonine phosphatase activity drug binding protein heterodimerization activity protein phosphatase
Process(es)
G1/S transition of mitotic cell cycle protein dephosphorylation protein import into nucleus calcium ion transport epidermis development positive regulation of cardiac muscle hypertrophy positive regulation of gene expression negative regulation of gene expression transition between fast and slow fiber cardiac muscle hypertrophy in response to stress dephosphorylation calcium-mediated signaling negative regulation of signaling keratinocyte differentiation positive regulation of cell migration calcineurin-NFAT signaling cascade multicellular organismal response to stress wound healing positive regulation of activated T cell proliferation T cell activation proteasome-mediated ubiquitin-dependent protein catabolic process skeletal muscle tissue regeneration positive regulation of osteoblast differentiation positive regulation of osteoclast differentiation positive regulation of cell adhesion positive regulation of endocytosis positive regulation of transcription from RNA polymerase II promoter positive regulation of saliva secretion skeletal muscle fiber development dendrite morphogenesis negative regulation of dendrite morphogenesis modulation of synaptic transmission response to calcium ion excitatory postsynaptic potential regulation of cell proliferation involved in kidney morphogenesis peptidyl-serine dephosphorylation renal sodium ion absorption positive regulation of calcineurin-NFAT signaling cascade positive regulation of glomerulus development renal filtration calcineurin-mediated signaling postsynaptic modulation of chemical synaptic transmission negative regulation of angiotensin-activated signaling pathway positive regulation of angiotensin-activated signaling pathway positive regulation of calcium ion-dependent exocytosis of neurotransmitter positive regulation of cardiac muscle hypertrophy in response to stress positive regulation of connective tissue replacement positive regulation of calcium ion import across plasma membrane negative regulation of calcium ion import across plasma membrane negative regulation of chromatin binding cellular response to drug negative regulation of insulin secretion positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of NFAT protein import into nucleus cellular response to glucose stimulus response to amphetamine negative regulation of calcium ion-dependent exocytosis
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