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Invitrogen
SETD1A Polyclonal Antibody
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FIGURE: 1 / 6
SETD1A Antibody (PA5-78298) in ICC/IF
Immunofluorescence analysis of SETD1A was performed using 70% confluent log phase HeLa cells. The cells were fixed with 4% paraformaldehyde for 15 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with SETD1A Polyclonal Antibody (Product # PA5-78298) at 1:100 dilution in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Recombinant Secondary Antibody, Alexa Fluor® 488 conjugat... View More
Product Details
PA5-78298
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the C-terminus region of human SETD1A. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1.18 mg/mL
Amount
118 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Predicted Reactivity: Bovine (90%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
SET1A is a component of a histone methyltransferase (HMT) complex that produces mono-, di-, and trimethylated histone H3 at Lys4. The complex is the analog of the S. cerevisiae Set1/COMPASS complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Histone-lysine N-methyltransferase SETD1A; hSET1A; Lysine N-methyltransferase 2F; non-selective cation channel 1; SET domain-containing protein 1A; Set1/Ash2 histone methyltransferase complex subunit SET1
Gene Aliases: BC010250; EPEDD; EPEO2; KIAA0339; KMT2F; mKIAA0339; mNSC1; NEDSID; Nsccn1; SET1; SET1A; SETD1A
UniProt ID: (Human) O15047, (Mouse) E9PYH6
Entrez Gene ID: (Human) 9739, (Mouse) 233904
nucleic acid binding
RNA binding
protein binding
beta-catenin binding
methyltransferase activity
transferase activity
histone methyltransferase activity (H3-K4 specific)
RNA polymerase II sequence-specific DNA binding transcription factor binding
histone H3 methyltransferase activity
histone H3K4 monomethyltransferase activity
histone H3K4 trimethyltransferase activity
histone-lysine N-methyltransferase activity
euchromatin binding
histone modifying enzyme
chromatin organization
chromatin remodeling
cellular response to DNA damage stimulus
brain development
methylation
regulation of hematopoietic stem cell differentiation
regulation of chromatin organization
stem cell population maintenance
chromatin-mediated maintenance of transcription
histone H3-K4 methylation
positive regulation of neural precursor cell proliferation
positive regulation of stem cell proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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