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Invitrogen

C1QBP Polyclonal Antibody

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C1QBP Polyclonal Antibody

Product Details

PA5-78890

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.5 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

0.5-1 µg/mL
-

Immunohistochemistry (Frozen) (IHC (F))

0.5-1 µg/mL
-

Immunocytochemistry (ICC/IF)

2 µg/mL
-

Flow Cytometry (Flow)

1-3 µg/1x10^6 cells
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

E. coli-derived human GC1q R recombinant protein (Position: E190-Q282).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS with 5mg BSA

Contains

0.05mg sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2746006

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: human Hela whole cell, human SW620 whole cell, human 293T whole cell, human A431 whole cell, rat brain tissue, rat spleen tissue, mouse brain tissue, mouse spleen tissue. IHC: mouse spleen tissue, rat spleen tissue, human tonsil tissue. ICC/IF: U20S cell. Flow: U20S cell.

Target Information

Replication Protein A (RPA) (also known as human single-stranded DNA binding protein, or HSSB) is involved in DNA replication, repair, and recombination. RPA from human cells is a stable heterotrimer of 70kDa, 32-34kDa, and 11-14kDa subunits (RPA70, RPA32, and RPA14 respectively). RPA is required for the SV40 large tumor antigen-catalyzed unwinding of SV40 DNA and stimulates DNA polymerase alpha and delta. RPA34 is phosphorylated at the G1/S boundary of the cell cycle or upon exposure of cells to DNA damage-inducing agents including ionizing and UV radiation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ASF/SF2-associated protein p32; C1q globular domain-binding protein; C1qBP; Complement component 1 Q subcomponent-binding protein, mitochondrial; complement component 1, q subcomponent binding protein; GC1q-R protein; Glycoprotein gC1qBP; Hyaluronan-binding protein 1; Mitochondrial matrix protein p32; p33; RPA; SF2AP32; splicing factor SF2-associated protein; unnamed protein product

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Gene Aliases: AA407365; AA986492; C1QBP; COXPD33; D11Wsu182e; gC1Q-R; GC1QBP; gC1qR; HABP1; P32; SF2AP32; SF2P32

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UniProt ID: (Human) Q07021, (Rat) O35796

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Entrez Gene ID: (Human) 708, (Rat) 29681, (Mouse) 12261

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Function(s)
complement component C1q binding transcription corepressor activity mRNA binding enzyme inhibitor activity protein kinase C binding protein binding hyaluronic acid binding transcription factor binding kininogen binding adrenergic receptor binding deoxyribonuclease inhibitor activity C5-methylcytidine-containing RNA reader activity mitochondrial ribosome binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter transcription, DNA-templated mRNA processing apoptotic process immune response complement activation, classical pathway RNA splicing phosphatidylinositol 3-kinase signaling regulation of complement activation negative regulation of interferon-gamma production negative regulation of interleukin-12 production negative regulation of MDA-5 signaling pathway negative regulation of RIG-I signaling pathway mature ribosome assembly positive regulation of apoptotic process innate immune response positive regulation of cell adhesion negative regulation of mRNA splicing, via spliceosome negative regulation of defense response to virus positive regulation of protein kinase B signaling positive regulation of mitochondrial translation positive regulation of neutrophil chemotaxis positive regulation of substrate adhesion-dependent cell spreading positive regulation of trophoblast cell migration positive regulation of dendritic cell chemotaxis immune system process regulation of transcription, DNA-templated ribosome biogenesis double-strand break repair via homologous recombination mitochondrial RNA catabolic process adaptive immune response cellular response to DNA damage stimulus protein kinase B signaling negative regulation of double-strand break repair via homologous recombination
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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