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Invitrogen

PKC mu Polyclonal Antibody

View all (40) PKC mu antibodies

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PKC mu Polyclonal Antibody

Product Details

PA5-83107

Applications
Tested Dilution
Publications

Western Blot (WB)

1 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human PRKD1. Recombinant protein control fragment (Product #RP-95008).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.4 mg/mL

Amount

40 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2790263

Product Specific Information

Immunogen sequence: RELECKIGER YITHESDDLR WEKYAGEQGL QYPTHLINPS ASHSDTPETE ETEMKALGER

Highest antigen sequence indentity to the following orthologs: Mouse - 83%, Rat - 83%.

Target Information

The PKC family of serine/threonine kinases, including PRKCN (PKD3), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent. PKC mu activation is dependent on the phosphorylation of two activation loop sites, Ser744 and Ser748, via a PKC-dependent signaling pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: DKFZP586E0820; nPKC-D1; nPKC-D2; nPKC-mu; nPKC-nu; PKC mu; PKC nu; PKC u; PKC v; PKC-u; PKC-v; PKCmu; PKCu; PKCv; PKD2; Protein kinase C mu type; Protein kinase C nu type; protein kinase C, mu; Protein kinase D; Protein kinase EPK2; Serine/threonine-protein kinase D1; Serine/threonine-protein kinase D2; Serine/threonine-protein kinase D3; unnamed protein product

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Gene Aliases: CHDED; EPK2; HSPC187; nPKC-D2; nPKC-NU; PKC-MU; PKC-NU; PKCM; PKD; PKD1; PKD2; PKD3; PRKCM; PRKCN; PRKD1; PRKD2; PRKD3

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UniProt ID: (Human) Q15139, (Human) Q9BZL6, (Human) O94806

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Entrez Gene ID: (Human) 5587, (Human) 25865, (Human) 23683

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Function(s)
nucleotide binding protein kinase activity protein serine/threonine kinase activity protein kinase C activity protein kinase C binding protein binding ATP binding zinc ion binding kinase activity transferase activity heat shock protein binding identical protein binding metal ion binding protein serine kinase activity phosphatidylinositol 3-kinase activator activity
Process(es)
angiogenesis positive regulation of endothelial cell proliferation adaptive immune response immune system process protein phosphorylation cell adhesion phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of endothelial cell migration sphingolipid biosynthetic process positive regulation of vascular endothelial growth factor receptor signaling pathway positive regulation of interleukin-2 production positive regulation of interleukin-8 production intracellular signal transduction cellular response to vascular endothelial growth factor stimulus positive regulation of blood vessel endothelial cell migration positive regulation of fibroblast growth factor receptor signaling pathway positive regulation of angiogenesis positive regulation of cell adhesion positive regulation of transcription from RNA polymerase II promoter vascular endothelial growth factor receptor signaling pathway T cell receptor signaling pathway positive regulation of T cell receptor signaling pathway positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of NF-kappaB transcription factor activity endothelial tube morphogenesis regulation of T cell apoptotic process positive regulation of ERK1 and ERK2 cascade positive regulation of DNA biosynthetic process positive regulation of endothelial cell chemotaxis apoptotic process inflammatory response Golgi organization signal transduction integrin-mediated signaling pathway nervous system development positive regulation of autophagy positive regulation of gene expression regulation of keratinocyte proliferation positive regulation of neuron projection development regulation of skeletal muscle contraction by modulation of calcium ion sensitivity of myofibril cell differentiation cellular response to amino acid starvation cellular response to oxidative stress positive regulation of protein import into nucleus positive regulation of I-kappaB kinase/NF-kappaB signaling cell-cell adhesion mediated by cadherin innate immune response positive regulation of osteoblast differentiation positive regulation of cell size negative regulation of endocytosis protein autophosphorylation positive regulation of protein export from nucleus Golgi vesicle transport defense response to Gram-negative bacterium regulation of release of sequestered calcium ion into cytosol positive regulation of protein kinase B signaling positive regulation of sarcomere organization transepithelial transport cellular response to hydroperoxide response to norepinephrine cellular response to norepinephrine stimulus positive regulation of peptide hormone secretion positive regulation of NLRP3 inflammasome complex assembly cellular response to angiotensin cellular response to phorbol 13-acetate 12-myristate cellular response to endothelin regulation of integrin-mediated signaling pathway
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