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PGRP-1a Polyclonal Antibody
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FIGURE: 1 / 1
PGRP-1a Antibody (PA5-98055) in WB
Western Blot analysis of PGRP-1a using a PGRP-1a Polyclonal antibody (Product # PA5-98055) at a concentration of 4.86 µg/mL. Positive WB detected in: MCF-7 whole cell lysate, Colo320 whole cell lysate. A secondary Goat polyclonal antibody to rabbit IgG was applied at a 1:50,000 dilution. Observed band size: 38 kDa.
Product Details
PA5-98055
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Peptidoglycan recognition protein 3 protein (90-222AA)
Conjugate
Form
Liquid
Concentration
4.86 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Primary immune recognition is based on structures common among invading pathogens. Bacterial surface molecules, such as lipopolysaccharide (LPS) and peptidoglycan (PGN), are known to elicit immune reactions ranging from cytokine release to fever. Recently, a family of proteins called peptidoglycan recognition protein (PGRP) has been identified in mouse and human that binds to peptidoglycans expressed on Gram-positive bacteria. Peptidoglycan (PGN) is an essential cell wall component of virtually all bacteria (1, 2) and, thus, it is an excellent target for recognition by the eukaryotic innate immune system. The PGRPs (PGRP-L, PGRP-S, PGRP-Ia, and PGRP-I beta) define a new family of human pattern recognition molecules (3). PGRP-L is primarily expressed in the liver. Although liver is not considered a primary immune organ, liver participates in host defenses by producing acute phase proteins (by hepatocytes) in response to infections and by clearing microorganisms from blood (4). PGRP-1a mRNA is highly expressed in esophagus, tonsils and thymus and to lesser extent in the stomach, rectum, and brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC149197; Peptidoglycan recognition protein 3; peptidoglycan recognition protein I alpha; Peptidoglycan recognition protein I-alpha; Peptidoglycan recognition protein intermediate alpha; PGLYRPIalpha; PGRP-I-alpha
Gene Aliases: PGLYRP3; PGLYRPIalpha; PGRP-Ialpha; PGRPIA
UniProt ID: (Human) Q96LB9
Entrez Gene ID: (Human) 114771
immune system process
immune response
peptidoglycan catabolic process
detection of bacterium
killing of cells of other organism
negative regulation of interferon-gamma production
negative regulation of natural killer cell differentiation involved in immune response
defense response to bacterium
innate immune response
defense response to Gram-positive bacterium
interaction with host
antimicrobial humoral immune response mediated by antimicrobial peptide
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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