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Invitrogen
PKA alpha/beta/gamma Polyclonal Antibody
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Product Details
PA5-99689
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human PRKACA(Accession P17612), corresponding to amino acid residues P314-F351.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total PKA alpha/beta/gamma CAT.
Target Information
Protein kinase A (PKA, cAMP-dependent protein kinase) is a key element of a ubiquitous signaling pathway important in the cell cycle, cellular communication, memory formation and behavior. PKA is composed of two catalytic (PKAc; Protein Kinase A catalytic subunit) and two regulatory subunits (PKAr). Upon binding cAMP, the complex dissociates to PKAr dimer and two activated PKAc ser/thr protein kinase catalytic monomers. The released PKAc can translocate into the nucleus and exert a regulatory role in the activation of multiple nuclear hormone receptors. However, PKAc-mediated activation of tonicity-dependent gene expression is cAMP independent. Humans express three types of PKAc subunit - PKAc alpha is present in most human tissues, PKAc beta and gamma are tissue-specific, the later is found in testes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-alpha-s; alternatively spliced isoform; cAMP-dependent protein kinase catalytic subunit alpha; cAMP-dependent protein kinase catalytic subunit beta; cAMP-dependent protein kinase catalytic subunit gamma; PKA C-alpha; PKA C-beta; PKA C-gamma; protein kinase A catalytic subunit; protein kinase A catalytic subunit beta; protein kinase, cAMP-dependent, alpha catalytic subunit; protein kinase, cAMP-dependent, beta catalytic subunit; protein kinase, cAMP-dependent, catalytic, alpha; protein kinase, cAMP-dependent, catalytic, beta; protein kinase, cAMP-dependent, catalytic, gamma; protein kinase, cAMP-dependent, gamma catalytic subunit; serine(threonine) protein kinase; unnamed protein product
Gene Aliases: BDPLT19; CAFD1; CAFD2; KAPG; PKA C-beta; PKACA; PKACB; PKACg; PPNAD4; PRKACA; PRKACB; PRKACG
UniProt ID: (Human) P17612, (Human) P22694, (Human) P22612
Entrez Gene ID: (Human) 5566, (Human) 5567, (Human) 5568
nucleotide binding
magnesium ion binding
protein kinase activity
protein serine/threonine kinase activity
cAMP-dependent protein kinase activity
protein serine/threonine/tyrosine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
protein kinase binding
protein domain specific binding
manganese ion binding
ubiquitin protein ligase binding
protein kinase A regulatory subunit binding
channel activator activity
protein serine kinase activity
renal water homeostasis
adenylate cyclase-activating G-protein coupled receptor signaling pathway
spermatogenesis
male gonad development
high-density lipoprotein particle assembly
vascular endothelial cell response to laminar fluid shear stress
mesoderm formation
neural tube closure
regulation of heart rate
mRNA processing
protein phosphorylation
protein export from nucleus
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
regulation of macroautophagy
peptidyl-serine phosphorylation
cytokine-mediated signaling pathway
cellular potassium ion homeostasis
cellular response to nutrient levels
positive regulation of insulin secretion
negative regulation of interleukin-2 production
cellular response to heat
mitochondrial protein catabolic process
interleukin-2-mediated signaling pathway
TORC1 signaling
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of cholesterol biosynthetic process
regulation of osteoblast differentiation
positive regulation of gluconeogenesis
negative regulation of smoothened signaling pathway
positive regulation of protein export from nucleus
sperm capacitation
positive regulation of phagocytosis
modulation of synaptic transmission
positive regulation of calcium-mediated signaling
regulation of cell cycle
regulation of cardiac muscle contraction
regulation of proteasomal protein catabolic process
cellular response to cold
regulation of protein processing
cellular response to glucose stimulus
cellular response to parathyroid hormone stimulus
cellular response to glucagon stimulus
cellular response to epinephrine stimulus
cell communication by electrical coupling involved in cardiac conduction
postsynaptic modulation of chemical synaptic transmission
cAMP/PKA signal transduction
regulation of cardiac conduction
negative regulation of TORC1 signaling
negative regulation of glycolytic process through fructose-6-phosphate
protein localization to lipid particle
regulation of bicellular tight junction assembly
signal transduction
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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