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Phospho-BTK (Tyr551) Polyclonal Antibody, FITC

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Phospho-BTK (Tyr551) Polyclonal Antibody, FITC

Product Details

PBTK-FITC

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-
Product Specifications

Species Reactivity

Human, Mouse, Non-human primate, Pig, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to Human BTK amino acids 544-561 (phopsho Y551). Sequence RYV LDD EY(p)T SSV GSK FPV
3D Epitope / Immunogen

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra spectra

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Bruton tyrosine kinase (BTK) is a cytoplasmic tyrosine kinase belonging to the SRC-related TEC subfamily of tyrosine kinases. Mutations in the BTK gene have been linked to severe developmental blocks in human B-cell ontogeny and immunodeficiency disorders. It has recently been shown to interact with members of the toll-like receptor (TLR) family such as TLR4, 6, 8, and 9. The TLRs are critical molecules in both the innate and adaptive immunity and can recognize diverse microbial pathogens. BTK has also been shown to interact with key proteins involved in TLR4 signal transduction such as MyD88, TIRAP, and IRAK, but not TRAF-6, suggesting that BTK is involved in lipopolysaccharide signal transduction.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: agammaglobulinaemia tyrosine kinase; Agammaglobulinemia tyrosine kinase; ATK; B-cell progenitor kinase; BPK; Bruton agammaglobulinemia tyrosine kinase; Bruton tyrosine kinase; Bruton's tyrosine kinase; dominant-negative kinase-deficient Brutons tyrosine kinase; frameshift mutation results in truncated protein; Kinase EMB; MGC126261; MGC126262; OTTHUMP00000023677; RP1-164F3.2; Tyrosine-protein kinase BTK; Tyrosine-protein kinase BTK (Brutons tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB); unnamed protein product; X-linked immune deficiency

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Gene Aliases: AGMX1; AI528679; AT; ATK; BPK; BTK; IGHD3; IMD1; PSCTK1; xid; XLA

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UniProt ID: (Human) Q06187, (Mouse) P35991

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Entrez Gene ID: (Human) 695, (Pig) 100627308, (Rat) 367901, (Mouse) 12229

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Function(s)
nucleotide binding protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity protein binding ATP binding phosphatidylinositol-3,4,5-trisphosphate binding zinc ion binding lipid binding phospholipase activator activity kinase activity transferase activity identical protein binding phospholipase binding metal ion binding receptor binding transferase activity, transferring phosphorus-containing groups
Process(es)
adaptive immune response histamine secretion by mast cell protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway I-kappaB kinase/NF-kappaB signaling response to organic substance peptidyl-tyrosine phosphorylation cell differentiation cellular response to reactive oxygen species peptidyl-tyrosine autophosphorylation regulation of cell proliferation innate immune response protein autophosphorylation cell maturation T cell receptor signaling pathway B cell receptor signaling pathway cellular response to molecule of fungal origin neutrophil homeostasis positive regulation of type III hypersensitivity positive regulation of type I hypersensitivity negative regulation of cytokine production B cell affinity maturation immune system process positive regulation of immunoglobulin production regulation of B cell cytokine production MyD88-dependent toll-like receptor signaling pathway regulation of B cell apoptotic process apoptotic process mesoderm development calcium-mediated signaling proteoglycan catabolic process negative regulation of B cell proliferation positive regulation of B cell proliferation positive regulation of type I interferon production response to lipopolysaccharide negative regulation of interleukin-10 production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production intracellular signal transduction Fc-epsilon receptor signaling pathway B cell activation positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of B cell differentiation positive regulation of phagocytosis regulation of B cell activation negative regulation of B cell activation positive regulation of NF-kappaB transcription factor activity monocyte proliferation negative regulation of leukocyte proliferation apoptotic signaling pathway cellular response to interleukin-7 cGAS/STING signaling pathway positive regulation of cGAS/STING signaling pathway positive regulation of interleukin-17A production positive regulation of NLRP3 inflammasome complex assembly positive regulation of synoviocyte proliferation eosinophil homeostasis transcription, DNA-templated regulation of transcription, DNA-templated phosphorylation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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