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PLCL1 Polyclonal Antibody
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Product Details
BS-4151R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human PLCL1, amino acids 1001-1095.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor. Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as a inhibitor of PPP1C.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 130kDa-Ins(1,4,5)P3 binding protein; Inactive phospholipase C-like protein 1; p130; phospholipase C, epsilon; phospholipase C, eta 2 pseudogene; Phospholipase C-deleted in lung carcinoma; phospholipase C-like 1; Phospholipase C-related but catalytically inactive protein; PLC-L1; PRIP; PRIP1; protein phosphatase 1, regulatory subunit 127; unnamed protein product
Gene Aliases: C230017K02Rik; PLC-L; PLC-L1; PLCE; PLCL; PLCL1; PLDL1; PPP1R127; PRIP; PRIP-1
UniProt ID: (Human) Q15111, (Mouse) Q3USB7, (Rat) Q62688
Entrez Gene ID: (Human) 5334, (Mouse) 227120, (Rat) 84587
lipid metabolic process
signal transduction
gamma-aminobutyric acid signaling pathway
regulation of synaptic transmission, GABAergic
intracellular signal transduction
phosphatidylinositol metabolic process
phosphatidylinositol-mediated signaling
release of sequestered calcium ion into cytosol
negative regulation of cold-induced thermogenesis
regulation of peptidyl-serine phosphorylation
positive regulation of receptor binding
lipid catabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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