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Proteintech
PTPN23 Polyclonal Antibody
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Product Details
10472-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PTPN23 Fusion Protein Ag0765 (420-619 aa encoded by BC004881)
Conjugate
Form
Liquid
Concentration
0.38 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: QEKLHLRFC YEAVVRHVEQ VLQRHGVPPP CKPLASASIS QKNHLPQDSQ DLVLGGDVPI SSIQATIAKL SIRPPGGLES PVASLPGPAE PPGLPPASLP ESTPIPSSSP PPLSSPLPEA PQPKEEPPVP EAPSSGPPSS SLELLASLTP EAFSLDSSLR GKQRMSKHNF LQAHNGQGLR ATRPSDDPLS LLDPLWTLNK T (420-619 aa encoded by BC004881)
Target Information
Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: HD-PTP; His domain-containing protein tyrosine phosphatase; Protein tyrosine phosphatase TD14; PTP-TD14; Tyrosine-protein phosphatase non-receptor type 23
Gene Aliases: HD-PTP; HDPTP; KIAA1471; PTP-TD14; PTPN23
UniProt ID: (Human) Q9H3S7
Entrez Gene ID: (Human) 25930
negative regulation of epithelial cell migration
protein transport
peptidyl-tyrosine dephosphorylation
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
cilium morphogenesis
positive regulation of homophilic cell adhesion
positive regulation of adherens junction organization
positive regulation of early endosome to late endosome transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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