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Invitrogen

RUNX1/RUNX2/RUNX3 Recombinant Rabbit Monoclonal Antibody (SD0803)

View all (5) RUNX1/RUNX2/RUNX3 antibodies

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RUNX1/RUNX2/RUNX3 Recombinant Rabbit Monoclonal Antibody (SD0803)

Product Details

MA5-32373

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

Flow Cytometry (Flow)

1:50-1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

SD0803

Immunogen

Synthetic peptide within Human RUNX1 aa 404-453.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 40% Glycerol, 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2809654

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are welldocumented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Acute myeloid leukemia 1 protein; Acute myeloid leukemia 2 protein; Acute myeloid leukemia 3 protein; acute myeloid leukemia gene 2; AKV core binding factor; aml1; AML1-ETO fusion; AML1-ETO fusion protein; AML1-EVI-1 fusion protein; CBF-alpha-1; CBF-alpha-2; CBF-alpha-3; core binding factor alpha 1; core binding factor alpha 2; core binding factor alpha 3; core-binding factor runt domain alpha subunit 2 (acute myeloid leukemia 1 oncogene); Core-binding factor subunit alpha-1; Core-binding factor subunit alpha-2; Core-binding factor subunit alpha-3; core-binding factor, runt domain, alpha subunit 1; core-binding factor, runt domain, alpha subunit 2; core-binding factor, runt domain, alpha subunit 3; mutant RUNX1; Oncogene AML-1; Oncogene AML-2; Oncogene AML-3; OSF-2; Osteoblast-specific transcription factor 2; PEA2 alpha C; PEA2-alpha A; PEA2-alpha B; PEA2-alpha C; PEBP2 alpha A; PEBP2 alpha C; PEBP2-alpha A; PEBP2-alpha B; PEBP2-alpha C; Polyomavirus enhancer-binding protein 2 alpha A subunit; Polyomavirus enhancer-binding protein 2 alpha B subunit; Polyomavirus enhancer-binding protein 2 alpha C subunit; runt domain, alpha subunit 1; runt domain, alpha subunit 2; runt domain, alpha subunit 3; runt related transcription factor 1; runt related transcription factor 2; Runt related transcription factor 3; Runt-related transcription factor 1; Runt-related transcription factor 2; Runt-related transcription factor 3; RUNX 2; RUNX-2; RUNX1 with skipped exon 5; SL3-3 enhancer factor 1 alpha A subunit; SL3-3 enhancer factor 1 alpha B subunit; SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV core-binding factor alpha A subunit; SL3/AKV core-binding factor alpha B subunit; SL3/AKV core-binding factor alpha C subunit; transcription factor AML2; transcription factor AML2/CBFA3; unnamed protein product

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Gene Aliases: AML1; AML1-EVI-1; AML2; AML3; AMLCR1; Cbf; CBF-alpha-1; CBF-alpha-2; CBF2alpha; Cbfa-1; CBFA1; CBFA2; CBFA3; CCD; CCD1; CLCD; EVI-1; LS3; OSF-2; OSF2; PEA2aA; PEBP2A; Pebp2a1; Pebp2a2; PEBP2A3; PEBP2aA; PEBP2aB; PEBP2aC; PEBP2alpha; Pebpa2a; Pebpa2b; RUNX1; RUNX2; RUNX3

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UniProt ID: (Human) Q01196, (Human) Q13950, (Human) Q13761, (Rat) Q63046, (Mouse) Q08775, (Mouse) Q64131

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Entrez Gene ID: (Human) 861, (Human) 860, (Human) 864, (Rat) 50662, (Mouse) 12394, (Rat) 367218, (Mouse) 12393, (Mouse) 12399, (Rat) 156726

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription corepressor binding transcription coactivator binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding calcium ion binding protein binding ATP binding protein homodimerization activity protein heterodimerization activity DNA-binding transcription factor binding sequence-specific double-stranded DNA binding core promoter proximal region sequence-specific DNA binding chromatin binding protein domain specific binding chromatin DNA binding bHLH transcription factor binding regulatory region DNA binding core promoter binding molecular_function transcription factor binding repressing transcription factor binding RNA polymerase II core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding histone deacetylase binding transcription regulatory region DNA binding Runt transcription factor DNA-binding transcription factor immunoglobulin fold transcription factor gene-specific transcriptional regulator
Process(es)
negative regulation of transcription from RNA polymerase II promoter ossification chondrocyte differentiation myeloid leukocyte differentiation regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter regulation of plasminogen activation hemopoiesis myeloid cell differentiation neuron differentiation negative regulation of granulocyte differentiation positive regulation of granulocyte differentiation positive regulation of interleukin-2 production positive regulation of collagen biosynthetic process negative regulation of CD4-positive, alpha-beta T cell differentiation positive regulation of CD8-positive, alpha-beta T cell differentiation regulation of cell differentiation positive regulation of angiogenesis positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter peripheral nervous system neuron development positive regulation of developmental process positive regulation of multicellular organismal process regulation of cardiac muscle cell proliferation cardiac muscle tissue regeneration hematopoietic stem cell proliferation positive regulation of extracellular matrix organization regulation of connective tissue replacement regulation of multicellular organismal development skeletal system development osteoblast differentiation endochondral ossification osteoblast fate commitment chondrocyte development osteoblast development transmembrane receptor protein serine/threonine kinase signaling pathway smoothened signaling pathway cell proliferation positive regulation of cell proliferation gene expression regulation of gene expression positive regulation of gene expression cell differentiation T cell differentiation regulation of ossification bone mineralization BMP signaling pathway positive regulation of chondrocyte differentiation embryonic forelimb morphogenesis ligamentous ossification regulation of fibroblast growth factor receptor signaling pathway odontogenesis of dentin-containing tooth regulation of odontogenesis of dentin-containing tooth regulation of osteoblast differentiation positive regulation of osteoblast differentiation negative regulation of smoothened signaling pathway negative regulation of transcription, DNA-templated cell maturation embryonic cranial skeleton morphogenesis skeletal system morphogenesis stem cell differentiation epithelial cell proliferation positive regulation of epithelial cell proliferation SMAD protein signal transduction stem cell proliferation response to sodium phosphate positive regulation of stem cell proliferation protein phosphorylation negative regulation of cell cycle negative regulation of epithelial cell proliferation response to transforming growth factor beta in utero embryonic development liver development myeloid progenitor cell differentiation transcription, DNA-templated central nervous system development negative regulation of cell proliferation regulation of signal transduction hair follicle morphogenesis response to retinoic acid embryonic hemopoiesis behavioral response to pain neuron development definitive hemopoiesis regulation of hair follicle cell proliferation cellular response to transforming growth factor beta stimulus positive regulation of cell maturation positive regulation of progesterone secretion regulation of T cell anergy transcription from RNA polymerase II promoter positive regulation of interferon-gamma production cellular response to fibroblast growth factor stimulus positive regulation of ossification cellular response to BMP stimulus positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus axon guidance neuron projection development interferon-gamma production mRNA transcription from RNA polymerase II promoter positive regulation of extrinsic apoptotic signaling pathway biological_process
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