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OriGene
PRMT2 Monoclonal Antibody (OTI3B3), TrueMAB™
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Product Details
TA503588
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI3B3
Immunogen
Full length human recombinant protein of human PRMT2 produced in HEK293T cell.
Conjugate
Form
Liquid
Concentration
0.68 mg/mL
Amount
68 µg
Purification
Affinity chromatography
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Histone-arginine N-methyltransferase PRMT2; HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 1; HMT1 hnRNP methyltransferase-like 1; HRMT1L1; MGC111373; PRMT2 alpha; PRMT2 beta; PRMT2 gamma; Protein arginine N-methyltransferase 2; unnamed protein product
Gene Aliases: HMT1; HRMT1L1; PRMT2
UniProt ID: (Human) P55345
Entrez Gene ID: (Human) 3275
transcription coactivator activity
protein binding
methyltransferase activity
protein-arginine N-methyltransferase activity
transferase activity
estrogen receptor binding
progesterone receptor binding
protein-arginine omega-N asymmetric methyltransferase activity
histone methyltransferase activity
protein homodimerization activity
retinoic acid receptor binding
peroxisome proliferator activated receptor binding
macromolecular complex binding
thyroid hormone receptor binding
androgen receptor binding
histone H3R8 methyltransferase activity
histone H3 methyltransferase activity
chromatin remodeling
regulation of transcription, DNA-templated
protein methylation
signal transduction
negative regulation of NF-kappaB transcription factor activity
methylation
positive regulation of apoptotic process
negative regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
developmental cell growth
negative regulation of inflammatory response
regulation of androgen receptor signaling pathway
negative regulation of G1/S transition of mitotic cell cycle
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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