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Hematopoietic Stem Cells (HSCs)
Hematopoietic stem cells (HSCs) are primarily found in the bone marrow and are also present in peripheral blood and umbilical cord blood. These multipotent stem cells are responsible for lifelong blood formation (hematopoiesis), continuously replenishing all blood cell types. HSCs can self-renew and differentiate into mature blood cells but do not generate cells of unrelated tissues.
HSCs play a critical role in research on blood disorders and hematologic malignancies. CD34 is a widely used marker for identifying human HSCs. We offer serum-free media for CD34+ cells, along with tools and methods to isolate CD34+ cells from blood or bone marrow to support your research.
Key characteristics of hematopoietic stem cells (HSCs)
In research settings, hematopoietic stem cells (HSCs) are defined operationally, based on demonstrated function rather than a single identifying marker. In practice, this means HSCs are characterized by:
- The ability to self-renew and sustain long-term, multilineage blood formation
- Validation through functional assays, most notably long-term repopulation after transplantation
- Enrichment using established surface marker combinations that vary by species and context
- A combination of phenotypic markers and proven functional capacity
Step-by-step guide to hematopoietic stem cell research products
Both iPSCs and primary tissue (e.g., mobilized peripheral blood, bone marrow, and cord blood) are popular sources for HSCs. Our StemPro-34 SFM is a well-referenced tool for driving iPSCs to HSCs.
Recommended products:
- Media and reagents
- Isolation
Learn more:
Engineer your hematopoietic stem cells to analyze gene and protein expression and study differentiation and disease pathways. Choose from lipid, electroporation, and viral-based delivery products, as well as a range of cloning technologies including, Gateway and TOPO Cloning.
Recommended products:
- CTS Xenon Electroporation System
- Neon NxT Electroporation System
- LV-MAX Lentiviral Production System
- Gateway Recombination Cloning Technology
Learn more:
We offer a number of high-quality growth factors and cytokines for targeted differentiation of hematopoietic stem cells (HSCs) into the blood cell types from the myeloid and lymphoid lineages. These proteins are extensively tested to help ensure high biological activity, high purity, freeze-thaw stability, and structural homogeneity.
In addition, our large portfolio of cell culture media and reagents, along with our custom media services, allow optimal growth, expansion, and storage of these differentiated cells.
Recommended products:
- Growth factors
- Media and reagents
Learn more:
We offer researchers a selection of cell stains and dyes, gene expression kits, and hematopoietic lineage-specific markers to validate pluripotency, differentiation status, and cell health.
Recommended products:
- Dyes
- Protein expression analysis
- Instruments
Learn more:
We provide a comprehensive set of resources for stem cell research including print and video protocols, product citations, tips and tricks, and technical support.
Technical information:
Both iPSCs and primary tissue (e.g., mobilized peripheral blood, bone marrow, and cord blood) are popular sources for HSCs. Our StemPro-34 SFM is a well-referenced tool for driving iPSCs to HSCs.
Recommended products:
- Media and reagents
- Isolation
Learn more:
Engineer your hematopoietic stem cells to analyze gene and protein expression and study differentiation and disease pathways. Choose from lipid, electroporation, and viral-based delivery products, as well as a range of cloning technologies including, Gateway and TOPO Cloning.
Recommended products:
- CTS Xenon Electroporation System
- Neon NxT Electroporation System
- LV-MAX Lentiviral Production System
- Gateway Recombination Cloning Technology
Learn more:
We offer a number of high-quality growth factors and cytokines for targeted differentiation of hematopoietic stem cells (HSCs) into the blood cell types from the myeloid and lymphoid lineages. These proteins are extensively tested to help ensure high biological activity, high purity, freeze-thaw stability, and structural homogeneity.
In addition, our large portfolio of cell culture media and reagents, along with our custom media services, allow optimal growth, expansion, and storage of these differentiated cells.
Recommended products:
- Growth factors
- Media and reagents
Learn more:
We offer researchers a selection of cell stains and dyes, gene expression kits, and hematopoietic lineage-specific markers to validate pluripotency, differentiation status, and cell health.
Recommended products:
- Dyes
- Protein expression analysis
- Instruments
Learn more:
We provide a comprehensive set of resources for stem cell research including print and video protocols, product citations, tips and tricks, and technical support.
Technical information:
Resources
Support
For Research Use Only. Not for use in diagnostic procedures.
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