CaptureSelect Affinity Products

These features make CaptureSelect products the right tools for small-scale protein purification. The products are specific for a wide variety of target proteins and are therefore well suited to a variety of applications:

• Small-scale protein purification—ready-to-use affinity resins, including:

• Antibody Toolbox® products for the separation of immunoglobulin formats from a wide range of environments, such as plasma, milk from transgenic animals, or supernatant from mammalian cell cultures
• Proteomics Toolbox® products for protein depletion to support biomarker research applications

• HPLC analytical chromatography columns—rapid, sensitive, and precise quantitation and small-scale sample preparation of proteins from complex mixtures
• Custom ligand design—the development of antibody ligands against a specific protein or impurity, enabling affinity purification tailored to novel applications

Most biomolecules can be purified with one of these products. Unlike the common bacterial coat protein components proteins A, G, and L, CaptureSelect affinity ligands are developed with defined specificity and high avidity to the target, enabling the creation of affinity chromatography resins well suited for single-step protein purification (Tables 1 and 2).

Table 1. Comparison of CaptureSelect affinity products.

BLI: bio-layer interferometry; PTM: post-translational modifications; SPR: surface plasmon resonance.

Table 2. POROS CaptureSelect analytical columns.