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2025 HLA Matchmaker Made Easy Series

This Program will delve into the concepts of HLA epitopes recognized by antibodies, their importance for evaluating mismatch acceptability and understanding antibody patterns of sensitized transplant patients.

We will take a journey from the identification of Cross-Reactive Groups of antigens to the subsequent elucidation of epitopes from protein sequences and three-dimensional structures of HLA alleles that underpin their cross reactivity. The structural basis and definition of epitopes will be explained along with methods of determining immunogenicity and their application in antibody analysis and epitope matching.

Episode Title Instructor Information

Introduction to Epitopes: Part I

Shari Turner, CHS(ACHI) MB(ASCP)-Sr. Technical Training Specialist-Antibody

Recorded date:
February 25th, 2025

Length:
41 minutes

Defining HLA Epitopes: Part II

James Jones, CHS(ACHI) MB(ASCP)-Sr. Technical Training Specialist-Antibody

Recorded date:
April 29th, 2025

Length:
58 minutes

Epitope Analysis: Class I 

Shari Turner, CHS(ACHI) MB(ASCP)-Sr. Technical Training Specialist-Antibody

Recorded date:
June 24th, 2025

Length:
56 minutes