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Learning Center
Expand your knowledge of HLA antibodies and molecular typing.
Learn the latest HLA technical and clinical advancements in transplant diagnostics. We have hands-on workshops geared to beginner and advanced HLA technicians who want to learn how to troubleshoot and analyze data results. We also host webinars or symposia at global transplant societies, including ASHI, EFI, and BSHI where you can interact with industry leaders to discuss the latest techniques and procedures.
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HistoTrac Virtual Series
HistoTrac is a powerful tool to manage laboratory data and streamline workflows. The software has several modules and functions that allow for creating various custom configurations and types of analysis in order to create a system that fits your individual lab’s needs perfectly.
2024 Virtual Software Training
This series of six virtual workshops trains users on how to use One Lambda™ LABType™ assays, TypeStream™ Visual 3.1 software, LABScreen™ assays, AllType™ NGS assays, AllType™ FASTplex™ assays, HistoTrac and HLA Fusion™ 4.7 software. This series will run every other month from February through December.
Back to Basics Virtual Series
Join this six part series to learn the basics and fundamental principals of HLA. Program will run from January through November of 2024.
PubSummary | HLA-OLI: A new MHC class I pseudogene and HLA-Y are located on a 60 kb indel in the human MHC between HLA-W and HLA-J
The identification of a new locus in the MHC demonstrates that much is to be learned about MHC diversity and how this may impact HCT outcomes.
2023 Virtual Software Training
This series of six virtual workshops trains users on how to use LABType assays, TypeStream Visual software, LABScreen assays, AllType NGS assays, AllType FASTplex assays, and HLA Matchmaker software.
Versatile Solutions for Human Leukocyte Antigen Testing with Peripheral Blood
Watch this on-demand webinar to see industry professionals showcase how high-quality DNA positively impacts the typing process and highlight the importance of quality checks on the NGS workflow.
White Paper | Improving The Efficiency And Reliability Of Post-Transplantation Monitoring And Prognosis
Read this white paper to learn more about improving the efficiency and reliability of post-transplantation surveillance and prognosis with the goal of improving long-term transplant outcomes.
PubSummary | Imlifidase for Kidney Transplantation of Highly Sensitized Patients With a Positive Crossmatch: The French Consensus Guidelines
A summary of the recent publication outlining French guidelines to define the use of Imlifidase, including patient selection criteria, monitoring frequencies, and associated treatment recommendations.
White Paper | The Role of Chimerism Following Hematopoietic Stem Cell Transplantation
Read this white paper to learn more about how monitoring for chimerism in patients after hematopoietic stem cell transplantation helps inform clinical decisions by providing invaluable information.
Detection of dd-cfDNA from Both Grafts in the Setting of a Second Kidney Transplantation by a New NGS-Based Assay
Watch this on-demand webinar to see Dr. Jakob Nilsson discuss a new NGS-based assay used to detect donor-derived cell-free DNA from grafts when monitoring patients after a kidney transplantation.
Molecular Assessment of Rejection in Pediatric Heart Transplantation: A Complement to Histopathology
Watch this webinar to hear Drs. Magnetta and Arva discuss MMDx Heart, a tool that combines histopathology with molecular techniques to provide a more accurate diagnosis for organ transplant rejection.
Introducing the HLA Assay as a Companion Diagnostic in Immunotherapy Development
Watch this webinar to see Dr. Sean Carey and Lee-Anne Zinetti highlight the critical role of HLA in cancer immunotherapy and overview the development of a companion diagnostic for precision medicine.
PubSummary | Discovery and Validation of a Urinary Exosome mRNA Signature for the Diagnosis of Human Kidney Transplant Rejection
Analyzing urinary exosomes is a simple and effective method of post-transplant monitoring. The mRNA profiles have high predictive abilities for both any-cause rejection and T cell–mediated rejection.
Discovering the Power of HistoTrac Software for Your HLA Laboratory | Yanping Huang
Listen to Dr. Yanping Huang detail the journey of her HLA lab implementing HistoTrac software. Discover the capabilities of the software’s basic functions, custom modules, and new management system.
PubSummary | Complement-Binding Anti-HLA Antibodies and Kidney-Allograft Survival
Learn how a C1q-binding assay significantly increases the ability to predict antibody mediated rejection and graft loss. C1q is a useful tool to manage renal patients post-transplantation.
Selecting and Implementing Next-Generation DNA Sequencing HLA Genotyping | Gerald Morris
NGS is becoming cheaper and easier for resolving ambiguities in HLA alleles. In this talk from our User Group Meeting 2022, Dr. Gerald Morris discussed how smaller labs could introduce NGS genotyping.
Extended HLA Antibody Profiling: How Might it Help in Immunological Risk of Assessment in the Era of Histocompatibility Testing | Siva Kanangat
At our 2022 User Group Meeting, Dr. Siva Kanangat shares a presentation on extended HLA antibody profiling as a tool for immunological risk assessment in histocompatibility testing.
Understanding Epitopes | Dave Lowe
This 2022 User Group Meeting talk highlights how tools to identify epitope-specific patterns are now available as sophisticated software suites for histocompatibility testing in transplantation.
Site-Directed Mutagenesis of HLA Molecules: A New Approach for HLA Eplet Verification
Dr. Suzanne Bezstarosti shared an approach to epitope differentiation with site-directed mutagenesis and discusses how the exact binding residues of HLA-specific monoclonal antibodies were evaluated.
A Proposed Update for the Definition of HLA Serologic Specificities Considering Structural Features that Determine Serologic Epitopes
During this User Group Meeting session, the speakers proposed an updated HLA nomenclature system that would enable any HLA allele to be delineated into one of a group of designated serotypes.
Treating Sera with Non-Specific Interference in SAB Assays | Luis Hidalgo
In our User Group Meeting, Dr. Luis Hidalgo discussed a variety of cases where our PreSorb reagent impacted unexpected reaction patterns in single antigen bead tests.
A Roadmap for Novel HLA Alleles from Discovery to Submission | Ahmed Mostafa
What constitutes a novel allele? Dr. Ahmed Mostafa defines what constitutes a novel allele and will demonstrate how to use TSV to identify one and submit the novel allele to the IPD-IMGT/HLA database.
PubSummary | The Molecular Microscope Diagnostic System (MMDx) Interpretation of Solid Organ Allograft Biopsies: Restoring the Perspective
MMDx Kidney helps refine the histopathologist’s findings that is not possible through light microscopy and support ABMR diagnosis where C4d or DSA results are either unavailable or negative.
The Value of MMDx in Diagnostic Uncertainty for Patients with Heart Transplantation: A Case-Based Presentation
In this presentation, Dr. Guha explores heart transplant patient cases in which clinical presentation and pathological diagnosis on biopsy are discrepant and gene expression profiling was used.
Video: APAC Virtual Workshop
This session features an overview of SureTyper, TypeStream Visual, HLA Fusion, HLA MatchMaker, and a discussion on virtual crossmatch testing with Donna Phelan.
AllType FASTplex NGS: Frag, Tag, Pool, and GO! | Dawn Thomas
Thinking of updating your NGS protocol to the new AllType FASTplex? See how Allogen Laboratories gained efficiencies by making the switch and the validation data.
Refining the HLA Antibody Assignment Using the LABScreen Single Antigen ExPlex Bead Panel
In this webinar, Drs. Liwski and Tafulo explore how some “pan-reactive” antibodies expressing less common HLA alleles can be dismissed as potential false positives.
LATAM Virtual Workshop
This session includes an introduction to the HLA Fusion functionality, and a review of challenging case studies of LABType, LABScreen, LinkSeq, and AllType.
LATAM Taller Virtual - Español
Esta sesión incluye una introducción a la funcionalidad HLA Fusion, una revisión de los estudios de casos desafiantes de LABType, LABScreen, LinkSeq, y AllType.
How Emerging Technologies Are Filling The Gaps And Positively Impacting Post-Transplant Care
Join Drs. Rajeev Sharma and Jamil Azzi to learn how new molecular solutions can provide clinical utility and enhance the patient experience. Valen Keefer provides a unique perspective to consider.
European Virtual Workshop
Learn key software functionality for HLA Fusion 4.6 and TypeStream Visual 2.1. Includes challenging AllType, LABType, LABScreen, and LinkSēq case studies, and an overview of HLA MatchMaker.
Novel Technology Has Made It Possible To Diagnose A New Clinical Phenotype Of Rejection Called Early Antibody Mediated Rejection, With Significant Therapeutic Implications For Renal Allograft Survival
Discover how MMDx Kidney can diagnose antibody-mediated rejection (AMBR) when histopathology is discordant with the clinical scenario. While there is still no FDA-approved treatment for ABMR. It is suggested that identifying early ABMR could lead to intervention and the prevention of graft loss due to chronic active ABMR.
US payer budget impact of a microarray assay with machine learning to evaluate kidney transplant rejection in for-cause biopsies
Dr. Chris Lawrence explores how a US payer budget model demonstrates that MMDx® Kidney is a cost-effective intervention despite the cost of the assay and the higher treatment costs associated with identifying more rejection.
Using Molecular Diagnostics for Kidney Transplants: Getting There! | Gaurav Gupta
Explore how molecular diagnostics can be used in clinical practice, including how the test can complement traditional histology as well as how the results can be incorporated into patient management.
The Transplant Journey and the Role of Clinical Diagnostics
While each person’s journey is unique, here is an overview of what you can expect to experience before, during, and after your transplant.
Case Study | A Challenging Diagnosis in Kidney Transplantation: MMDx Kidney
In a case where a highly sensitized patient received abnormal biopsy results after transplantation, gene expression profiling provided the treating clinician with confirmatory results for diagnosis.
Video: Non-HLA Antibodies: Preliminary Experience
A case study of nine patients that had high levels of REG3A, LMNB, PRKCH, GAPDH, HNRNPK, VM, and IFNG autoantibodies; correlated with humoral rejection in kidney and heart transplant recipients.
Video: HLA Typing by Next-Generation Sequencing (NGS) Using the AllType Fastplex Kit and the Relevance of Anti-HLA Antibody Monitoring After Kidney Transplantation
Dr. Andreani shares his laboratory’s evaluation of One Lambda™ AllType™ FASTPlex™ NGS showing 100% concordance on 240 and demonstrates how his lab determines a patient’s eplet load using HLAMatchmaker
Video: An Introduction to and the Evolution of the UK Living Kidney Sharing Scheme
Learn how Imlifidase specifically targets IgG and inhibits pathogenic IgG-mediated immune responses in transplant patients and patients with autoimmune disease or cancer.
PubSummary | Long Term Survival after Kidney Transplantation
Long-term kidney transplant graft and patient survival have improved with time due to a superior understanding of pre-transplant immunological risk.
Video: Advancements in AllType FASTPlex
Improvements include an optimized primer mix for 11 HLA loci, more robust PCR amplification, greater on-target accuracy, an improved DRB primer design, and better locus balance.
Video: Potential of Imlifidase
Learn how Imlifidase specifically targets IgG and inhibits pathogenic IgG-mediated immune responses in transplant patients and patients with autoimmune disease or cancer.
The Role of the HLA Laboratory
In this presentation, Dr. Dave Lowe gives patients and families a brief overview of the role that the HLA laboratory plays in transplantation.
Video: New Antibody Advances
Discussion on developments and quality improvements of our LABScreen antibody products and a discussion on the future of antibody testing.
UNOS Kidney Allocation: The Evolving Landscape | Cathi Murphey Half
A lab monitored kidney transplant statistics after the March 2021 point-based kidney allocation policy was implemented and used the UNOS kidney simulation model (KPSAM) to assess its predictive value.
Filling in the gaps: A Single-Center Experience with ExPlex | Kelley Hitchman
A laboratory was able to detect HLA reactivity that would have previously gone undetected in Hispanics without having to perform additional tests, saving time and resources.
AllType™ FASTplex™ v2: Our HLA Laboratory Experience | Ahmed Mostafa
Discover how NGS and antibody detection can be combined for broader applications, including virtual crossmatching, to support changes to the kidney allocation system.
Adapting Laboratory Diagnostics to a Changing Landscape | ASHI 2021
Discover how NGS and antibody detection can be combined for broader applications, including virtual crossmatching, to support changes to the kidney allocation system.
Clinical Applications for MMDx®: Gene Expression Profiling in Transplant Biopsies | Georg Böhmig
Molecular assessment was applied to diagnose allograft dysfunction and to determine if rejection was due to ABMR, TCMR, or a combination of both.
PubSummary | Intensity of de novo DSA detected by Immucor Lifecodes assay and C3d fixing antibodies are not predictive of subclinical ABMR after kidney transplantation
Bertrand et al. demonstrate that there are significant differences between HLA antibody test vendors in the ability to detect dnDSA in cases of biopsy-proven sABMR.
Are Dilutions the Solution? Identifying the True Extent of Patient Sensitization
In this presentation, Drs. Mark Stegall and Anat Tambur discuss how serial dilutions of the LABScreen™ Single Antigen assay aid in the assessment of alloantibody levels.
Video: LinkSēq™ for both HLA and Transfusion Products (Case Studies)
A high-level product overview of rt PCR products for HLA and Blood Transfusion, with case studies designed to highlight challenging sample analysis and critical points in the LinkSeq assay.
Video: LinkSēq™ for both HLA and Transfusion Products
In this session, we review key software functionality in both the latest SureTyper and SureTyper Blood analysis software applications.
White Paper | Research suggests HLA & HNA may play a critical role in COVID-19 Susceptibility, Immune Protection and Success of Novel Treatments during a Global Pandemic Crisis
We have the requisite HLA and HNA antibody screening products to protect patients from an adverse transfusion-related lung injury during upcoming convalescent plasma therapy trials.
Video: HLA MatchMaker | LABScreen™ Single Antigen Beads in HLA Fusion™ 4.6 (Case Studies)
In this session, case studies cover best practices of assay techniques to the utilization of software functionality for challenging sample analysis.
Video: HLA MatchMaker | LABScreen™ Single Antigen Beads in HLA Fusion™ 4.6
In this session, case studies cover best practices of assay techniques to the utilization of software functionality for challenging sample analysis.
The Quest for Better Kidney Care in Multicultural Communities | Carolyn Lemos-Urquidez
Carolyn of Kidneys Quest Foundation discusses the challenges of dialysis patient care in diverse and underserved communities and what you can do to help.
Video: LABType™ and Specific Case Studies
In this session, case studies cover best practices of assay techniques to the utilization of software functionality for challenging sample analysis.
Video: LABType™ and HLA Fusion™ 4.6
A comprehensive review of the LABType analysis module in HLA Fusion with emphasis placed on new features and functionality implemented in versions 4.0 and above.
PubSummary | A 2020 Banff Antibody Mediated Injury Working Group examination of international practices for diagnosing antibody mediated rejection in kidney transplantation
Biopsy data is accompanied by DSA data in +/- 30% of cases, suggesting urgent action to improve the accessibility of DSA information is needed.
PubSummary | Incidence and impact of allele-specific anti-HLA antibodies and high-resolution HLA genotyping on assessing immunologic compatibility
Allele specific anti-HLA reactivity was shown to occur in around 15% of patients awaiting transplantation.
Video: AllType™ & AllType FASTplex
Our instructors provide an introduction to our AllType and AllType FASTplex products plus an examination of challenging NGS case studies.
Video: TypeStream™ Visual 2.0.1
Learn data reporting and exporting, comparing results, plus new features like NGS configurations for analysis parameters, customizable health metrics.
Directory: Advanced Virtual Workshop Series
Learn how to process samples using LABType, LABScreen, AllType, and LinkSeq products as well as how to create custom analysis reports using HLA Fusion, TypeStream, and SureTyper software.
PubSummary | Analysis of RNA Transcripts by the Molecular Microscope Diagnostic System Can Direct Management after Indication Kidney Transplant Biopsy
These two cases describe how MMDx was used to aid the management of two patients with Banff diagnoses of “borderline” and “Banff 1a TCMR.”
PubSummary | Discrepancy analysis comparing molecular and histology diagnoses in kidney transplant biopsies
This study demonstrates the reproducibility of MMDx and the lack of significant disagreement between MMDx sign outs.
Innovations in Rejection Surveillance after Heart Transplantation | Jon Kobashigawa
For post-transplant management in heart patients, the endomyocardial biopsy is considered the gold standard to detect acute rejection.
PubSummary | Gene Expression Profiling for the Identification and Classification of Antibody-Mediated Heart Rejection
The study describes the molecular landscape of antibody mediated rejection.
Basic Immunology and the HLA Complex | Bedrich Prokupek
In the context of transplant medicine, this program will review immunology basics and the structure and function of the HLA complex for both Class I and Class II.
PubSummary | Revisiting the changes in the Banff Classification for antibody‐mediated rejection after kidney transplantation
In the search for potential treatments and personalized prognostication, a clear definition of antibody mediated rejection (ABMR) is an indispensable prerequisite.
Estimating Alloantibody Levels in Highly-Sensitized Renal Allograft Candidates
This study used serial dilution analysis to determine the point at which cPRA could be reduced below 98%, a value previously shown to significantly increase probability of transplant.
Changing the Conversation on Chronic Illness & Disability | Patient Stories
Our W-ERG LA Chapter organized this webinar to discuss the common challenges, biases, and misconceptions that those with a chronic illness or disability often face.
Vein to Vein: RBC Alloimmunization, Genotyping & Inventory Management | Drs. Stella Chou and Monica Kalvelage
Hear from industry leaders as they discuss transfusion medicine, challenges of finding donors, managing blood bank inventory, as well as the benefits of preventing alloimmunization.
Discovering novel injury features in kidney transplant biopsies associated with TCMR and donor aging
We previously characterized the molecular changes in acute kidney injury (AKI) and chronic kidney disease (CKD) in kidney transplant biopsies, but parenchymal changes selective for specific types ...
Increasing Access to Transplantation for the Highly Sensitized Patient: Combining the Latest Innovations in HLA Typing, Antibody Detection and Data Analysis | Taba Kheradmand and Robert Liwski
We explore how the evolution of more efficient NGS workflows and advanced Single Antigen assays with extended allele coverage can improve analysis with Epitope Matching and Virtual Crossmatching.
Introduction to the Molecular Microscope Diagnostic System (MMDx)
What is MMDx and how does it work? Dr. Christopher Lawrence gives a brief overview of the biopsy service.
Specimen Collection Procedure for the Molecular Microscope Diagnostics System (MMDx)
Thinking of ordering an MMDx specimen collection kit? See what's in the kit and how to collect the specimen and ship it to the lab for assessment.
The Role of Race in Transplant and Transfusion: a Roundtable Discussion | Patient Stories
HLA experts discuss the need for a more diverse donor pool and the impact that the COVID-19 pandemic is having on minority donor recruitment in transplant and transfusion.
Virtual crossmatch strategy to facilitate kidney transplantation for highly sensitized candidates | Rajalingam Raja
In this talk, Dr. Raja delves into key considerations for highly sensitized candidates.
The Quest to Decipher HLA Immunogenicity: Telling Friend from Foe | Anat Tambur
Dr. Tambur explores a new way to interrogate molecular mismatch load and discusses important concepts in immunogenicity.
The Molecular Microscope Diagnostic System: Precision and Accuracy in Transplant Diagnostics | Philip Halloran
Dr. Phil Halloran discusses the unmet need for precision and accuracy in pathological biopsy assessment and reviews the applications of the actionable data generated in MMDx reports.
The Kinetics of Anti-HLA Antibody in Simultaneous Liver-Kidney Transplantation | Matthew Cusick
Dr. Matthew Cusick will provide an assessment of the impact that DSAs may have on simultaneous liver-kidney transplants and discuss how the liver may play a key role in antibody clearance.
Allele-specific DSA: Lessons from SAB and NGS | Gerald P. Morris
Dr. Morris explores the limitations of solid-organ HLA genotyping methods that may preclude DSA identification and discussed various approaches for monitoring allele-specific anti-HLA antibodies.
The Power of Digital Storytelling to Educate, Empower, and Engage Patients and Prospective Living Donors | Amy Waterman
Dr. Waterman with UCLA and TREC shares how the true stories of transplant donors, recipients, and candidates have the power to save and change lives.
The Life-Saving Power of Transplantation and the Need for Further Transplant Innovations
Regina Armstrong, a 32-year heart transplant recipient and a recent kidney transplant recipient, is a One Legacy Ambassador and came to One Lambda to share her transplant journey.
Giving and Receiving the Gift of Life: Mona Castro Shares Her Family's Bittersweet Transplant Story
Mona Castro visited One Lambda to share her family’s poignant story of both giving and receiving the gift of life. Mona's daughter, Sara, is a two-time transplant recipient who was born with severe...
AllType Next Generation Sequencing – Easy Integration and Future Innovation | Elizabeth Wroe
Elizabeth Wroe showcased the NHSBT’s rigorous selection criteria and provided an in-depth look of the lab’s integration of the AllType NGS assay into routine laboratory practice.
New Frontiers in Expanded Single Antigen Testing | Jakob Nilsson
Dr. Jakob Nilsson gives a preliminary summary of his experience using LABScreen Single Antigen ExPlex, and assesses the test’s ability to predict possible binding epitopes through HLAMatchmaker.
The Evolution of Risk Assessment in Solid Organ Transplantation | Kelley Hitchman
Dr. Kelley Hitchman gives an overview of advancements in crossmatch testing, examines the practicality and advantages of virtual crossmatching, and reviews requirements that impact labs.
The Usefulness of Epitope Analysis When Interpreting HLA Antibody Test Results | Robert Liwski
Dr. Robert Liwski provides an overview of the HLAMatchmaker approach and explores the key role of epitope analysis in HLA antibody testing through literature review and case studies.
The Grief of Unexpected Loss, and the Healing Power of Deciding on Organ Donation
OneLegacy ambassador, Kim Payne, shared with us how she weathered the devastating loss of her grandson, Malaikye, by becoming an advocate for organ donation.
Assessing HLA Antibodies: Can we understand the strength? | Nicole Valenzuela
Learn about HLA antibody testing, interpretation of HLA antibody profiles, and the utility of serum dilution and C1qScreen in this discussion led by Dr. Nicole Valenzuela.
ABO Blood Subgrouping and Implications in Transplantation | William Lane
Understand ABO genotyping, how it enables ABO minor incompatible (ABOi) transplants and the technologies and resources that are available to help labs perform ABOi transplants.
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