Whether your researching Cytokine or KIR genes, we offer a variety of genotyping assays with different protocols to fit your laboratory needs.
Researchers are currently investigating the role of cytokine expression levels in diseases such as cancer, AIDS, and autoimmune diseases. Cytokines are crucial in cellular communication and are key elements in controlling the immune response. Research suggests that polymorphic variants of cytokine genes may be associated with acute and chronic transplant rejection. These variants express the corresponding cytokine gene at either elevated or reduced levels. Expression levels of TGF-beta, TNF-alpha, IL-10, and IL-6 appear to affect the likelihood of organ rejection.1 Genotyping of these polymorphic variants might be used to further investigate the role of cytokines in organ transplants.
The Cytokine Genotyping tray provides an accurate, simple, and economical means of detecting polymorphisms of the following cytokine genes:
We have developed a genotyping tool using sequence-specific primer polymerase chain reaction (SSP-PCR) technology to identify known Human neutrophil antigens (HNA) polymorphisms. HNA are involved in a variety of clinical conditions, including immune neutropenias, transfusion-related acute lung injury (TRALI), refractoriness to granulocyte transfusions and febrile transfusion reactions.
The KIR SSO Genotyping Test, featuring Luminex® xMAP® technology, is designed to promote further research on the impact of killer cell immunoglobulin-like receptors (KIRs). This test supports research on the effects of KIR mismatching in HLA-typed unrelated donor-recipient pairs.
The KIR Genotyping Kit identifies the presence or absence of the following genes: 2DL1, 2DL2, 2DL3, 2DL4, 2DL5, 2DS1, 2DS2, 2DS3, 2DS4, 2DS5, 3DL1, 3DL2, 3DL3, 3DS1, 2DP1, 3DP1, as well as the common variants of 2DL5, 2DS4, and 3DP1. Each tray contains 21 formulations of specific primer sets used to amplify genomic DNA. Four tests are contained on each tray. Includes PCR Buffer and a negative contamination control.
KIR play an important role in regulating Natural Killer (NK) cell activity. NK cells have been implicated in the promotion of engraftment and mediation of graft-versus-leukemia (GVL). These effects may be the result of donor-recipient HLA epitope mismatching for KIR.