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Proteintech
PKM Polyclonal Antibody
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Product Details
10078-2-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse,
Pig,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PKM Fusion Protein Ag0110 (11-221 aa encoded by BC000481)
Conjugate
Form
Liquid
Concentration
0.14 mg/mL
Amount
21 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody can recognize both PK-M1 and PK-M2.
Immunogen sequence: AFIQTQQLH AAMADTFLEH MCRLDIDSPP ITARNTGIIC TIGPASRSVE TLKEMIKSGM NVARLNFSHG THEYHAETIK NVRTATESFA SDPILYRPVA VALDTKGPEI RTGLIKGSGT AEVELKKGAT LKITLDNAYM EKCDENILWL DYKNICKVVE VGSKIYVDDG LISLQVKQKG ADFLVTEVEN GGSLGSKKGV NLPGAAVDLP AV (11-221 aa encoded by BC000481)
Target Information
This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CTHBP; Cytosolic thyroid hormone-binding protein; cytosolic thyroid hormone-binding protein (EC 2.7.1.40); epididymis secretory protein Li 30; m2pk; OIP-3; OPA-interacting protein 3; p58; PK, muscle type; Pyruvate kinase 2/3; pyruvate kinase 3; pyruvate kinase isozymes M1/M2; Pyruvate kinase muscle isozyme; Pyruvate kinase PKM; pyruvate kinase, muscle; similar to human pyruvate kinase M2; THBP1; Threonine-protein kinase PKM2; Thyroid hormone-binding protein 1; thyroid hormone-binding protein, cytosolic; Tumor M2-PK; Tyrosine-protein kinase PKM2; unnamed protein product
Gene Aliases: AA414905; AL024370; AL024424; CTHBP; HEL-S-30; OIP3; p58; Pk-2; Pk-3; PK2; PK3; PKM; PKM2; Pykm; TCB; THBP1
UniProt ID: (Human) P14618, (Mouse) P52480
Entrez Gene ID: (Human) 5315, (Mouse) 18746
nucleotide binding
magnesium ion binding
transcription coactivator activity
RNA binding
mRNA binding
catalytic activity
protein tyrosine kinase activity
pyruvate kinase activity
protein binding
ATP binding
kinase activity
transferase activity
MHC class II protein complex binding
potassium ion binding
histone kinase activity (H3-T11 specific)
protein homodimerization activity
cadherin binding
metal ion binding
ADP binding
poly(A) RNA binding
kinase
glycolytic process
chromatin remodeling
regulation of translation
programmed cell death
cellular response to insulin stimulus
positive regulation of transcription from RNA polymerase II promoter
canonical glycolysis
positive regulation of sprouting angiogenesis
positive regulation of cytoplasmic translation
liver development
glucose metabolic process
ATP biosynthetic process
metabolic process
phosphorylation
organ regeneration
pyruvate biosynthetic process
skeletal muscle tissue regeneration
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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