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Proteintech
SCIN Polyclonal Antibody
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Product Details
11579-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SCIN Fusion Protein Ag2168 (1-357 aa encoded by BC021090)
Conjugate
Form
Liquid
Concentration
0.23 mg/mL
Amount
34.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MARELYHEE FARAGKQAGL QVWRIEKLEL VPVPQSAHGD FYVGDAYLVL HTAKTSRGFT YRLHFWLGKE CSQDESTAAA IFTVQMDDYL GGKPVQNREL QGYESNDFVS YFKGGLKYKA GGVASGLNHV LTNDLTAKRL LHVKGRRVVR ATEVPLSWDS FNKGDCFIID LGTEIYQWCG SSCNKYERLK ANQVATGIRY NERKGRSELI VVEEGSEPSE LIKVLGEKPE LPDGGDDDDI IADISNRKMA KLYMVSDASG SMRVTVVAEE NPFSMAMLLS EECFILDHGA AKQIFVWKGK DANPQERKAA MKTAEEFLQQ MNYSKNTQIQ VLPEGGETPI FKQFFKDWRD KDQSDGFG (1-357 aa encoded by BC021090)
Target Information
The SCIN gene, also known as scinderin, encodes for a calcium-dependent actin filament-severing protein that is involved in the regulation of the cytoskeleton. It plays a significant role in actin filament dynamics, influencing cellular processes such as cell shape, motility, secretion, and division. SCIN has been identified as a novel oncogene, with its abnormal expression strongly correlated to various cancers, including glioma and uterine corpus endometrial carcinoma. Specific mutations like S673F and S381Y in SCIN are linked with poor prognosis and are potential targets for cancer diagnosis, prognosis, and treatment strategies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Adseverin; Gelsolin-like protein; Scinderin; unnamed protein product
Gene Aliases: adseverin; AW545522; KIAA1905; SCIN; Scind
UniProt ID: (Human) Q9Y6U3, (Mouse) Q60604
Entrez Gene ID: (Human) 85477, (Rat) 298975, (Mouse) 20259
central nervous system development
actin polymerization or depolymerization
negative regulation of cell proliferation
calcium ion regulated exocytosis
cell projection assembly
regulation of chondrocyte differentiation
positive regulation of apoptotic process
actin nucleation
positive regulation of megakaryocyte differentiation
actin filament severing
barbed-end actin filament capping
positive regulation of secretion
positive regulation of actin nucleation
actin filament capping
sequestering of actin monomers
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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