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Proteintech
GABRA4 Polyclonal Antibody
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Product Details
12979-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GABRA4 Fusion Protein Ag3600 (338-554 aa encoded by BC035055)
Conjugate
Form
Liquid
Concentration
0.57 mg/mL
Amount
85.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: AAVNYFTNI QMEKAKRKTS KPPQEVPAAP VQREKHPEAP LQNTNANLNM RKRTNALVHS ESDVGNRTEV GNHSSKSSTV VQESSKGTPR SYLASSPNPF SRANAAETIS AARALPSASP TSIRTGYMPR KASVGSASTR HVFGSRLQRI KTTVNTIGAT GKLSATPPPS APPPSGSGTS KIDKYARILF PVTFGAFNMV YWVVYLSKDT MEKSESLM (338-554 aa encoded by BC035055)
Target Information
Gamma-aminobutyric acid is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1. Alternatively spliced transcript variants encoding different isoforms have been found in this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: GABA(A) receptor; GABA(A) receptor subunit alpha-4; GABA(A) receptor, alpha 4; GABA-A receptor alpha-4 subunit; GABAAR subunit alpha-4; GABAARalpha4; gamma-aminobutyric acid; gamma-aminobutyric acid (GABA) A receptor, alpha 4; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 4; gamma-aminobutyric acid A receptor alpha 4; Gamma-aminobutyric acid receptor subunit alpha-4; gamma-aminobutyric acid type A receptor alpha4 subunit; unnamed protein product
Gene Aliases: Gabra-4; GABRA4
UniProt ID: (Human) P48169, (Mouse) Q9D6F4, (Rat) P28471
Entrez Gene ID: (Human) 2557, (Mouse) 14397, (Rat) 140675
transmembrane signaling receptor activity
GABA-A receptor activity
ion channel activity
extracellular ligand-gated ion channel activity
chloride channel activity
benzodiazepine receptor activity
GABA-gated chloride ion channel activity
signaling receptor activity
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
ligand-gated ion channel
ion transport
chloride transport
gamma-aminobutyric acid signaling pathway
central nervous system development
ion transmembrane transport
synaptic transmission, GABAergic
regulation of postsynaptic membrane potential
chloride transmembrane transport
inhibitory synapse assembly
transport
regulation of response to drug
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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