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Proteintech

MTMR6 Polyclonal Antibody

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MTMR6 Polyclonal Antibody

Product Details

13684-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2400
-

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

MTMR6 Fusion Protein Ag4551 (1-241 aa encoded by BC040012)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Amount

45 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MEHIRTTKV EQVKLLDRFS TSNKSLTGTL YLTATHLLFI DSHQKETWIL HHHIASVEKL ALTTSGCPLV IQCKNFRTVH FIVPRERDCH DIYNSLLQLS KQAKYEDLYA FSYNPKQNDS ERLQGWQLID LAEEYKRMGV PNSHWQLSDA NRDYKICETY PRELYVPRIA SKPIIVGSSK FRSKGRFPVL SYYHQDKEAA ICRCSQPLSG FSARCLEDEH LLQAISKANP VNRYMYVMDT RP (1-241 aa encoded by BC040012)

Target Information

Phosphatase that acts on lipids with a phosphoinositol headgroup (PubMed:19038970, PubMed:22647598). Dephosphorylates phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,5-bisphosphate (PubMed:19038970, PubMed:22647598) (Probable). Binds with high affinity to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) but also to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), phosphatidic acid and phosphatidylserine (PubMed:19038970). Negatively regulates ER-Golgi protein transport. Probably in association with MTMR9, plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3-phosphate in membrane ruffles (PubMed:24591580). Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4(+) T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3-phosphate (PubMed:15831468). Negatively regulates proliferation of reactivated CD4(+) T-cells (PubMed:16847315). In complex with MTMR9, negatively regulates DNA damage-induced apoptosis (PubMed:19038970, PubMed:22647598). The formation of the MTMR6-MTMR9 complex stabilizes both MTMR6 and MTMR9 protein levels (PubMed:19038970). [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: DSEG number: D13S824E; orf; hMTMR6; mtmr6; Myotubularin-related protein 6; phosphatidylinositol-3,5-bisphosphate 3-phosphatase; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6; Phosphatidylinositol-3-phosphate phosphatase; unnamed protein product

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Gene Aliases: 4022440C11Rik; AI428804; AU041072; MTMR6

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UniProt ID: (Human) Q9Y217, (Rat) A0A0G2JXT6, (Mouse) Q8VE11

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Entrez Gene ID: (Human) 9107, (Rat) 305935, (Mouse) 219135

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Function(s)
phosphatidylinositol-3-phosphatase activity protein serine/threonine phosphatase activity protein tyrosine phosphatase activity protein binding hydrolase activity phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity phosphatidylinositol-3,5-bisphosphate phosphatase activity calcium-activated potassium channel activity phosphatase activity protein tyrosine/serine/threonine phosphatase activity protein tyrosine/threonine phosphatase activity JUN kinase phosphatase activity phosphohistidine phosphatase activity inositol bisphosphate phosphatase activity MAP kinase tyrosine/serine/threonine phosphatase activity inositol-1,3,4-trisphosphate 4-phosphatase activity NADP phosphatase activity transmembrane receptor protein phosphatase activity inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity inositol-4,5-bisphosphate 5-phosphatase activity 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity phosphatidylinositol-4-phosphate phosphatase activity phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity inositol phosphate phosphatase activity inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity inositol-3,4-bisphosphate 4-phosphatase activity inositol-1,3,4-trisphosphate 1-phosphatase activity inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity IDP phosphatase activity phosphatase
Process(es)
protein dephosphorylation lipid metabolic process phosphatidylinositol biosynthetic process endocytosis phosphatidylinositol metabolic process phosphatidylinositol dephosphorylation dephosphorylation potassium ion transmembrane transport
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