Thermo Scientific Pierce BMPH is a short, maleimide-and-hydrazide crosslinker for conjugating sulfhydryls (cysteines) to carbonyls (aldehyde or ketones, such asRead more
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Catalog number 22297
Price (USD)/ 50 mg
166.00
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Price (USD)/ 50 mg
166.00
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BMPH (N-β-maleimidopropionic acid hydrazide)
Catalog number22297
Price (USD)/ 50 mg
166.00
-
Add to cart
Thermo Scientific Pierce BMPH is a short, maleimide-and-hydrazide crosslinker for conjugating sulfhydryls (cysteines) to carbonyls (aldehyde or ketones, such as those formed by oxidation of glycoprotein carbohydrates).
Features of BMPH:
• Reactive groups:maleimide and hydrazide • Reactive towards: sulfhydryl groups and carbonyl (aldehyde) groups • Short (8.1A), sulfhydryl-to-aldehyde crosslinker with simple spacer arm (noncleavable) • Maleimide group reacts with sulfhydryl groups to form stable thioether linkages • Hydrazide group conjugates to oxidized sugars of glycoproteins and carbohydrates • Use sodium meta-periodate to oxidize glycosylation (e.g., sialic acid) to reactive aldehyde groups • Use with EDC to conjugate primary amine of hydrazide group to carboxyl groups
Product References:
Crosslinker Application Guide -- search for recent literature references for this product