2'-OMe-PAC-A CEP is a phosphoramidite containing 5' DMT and the nucleoside adenosine (A) with 2'-O-methyl protection, for use in oligonucleotide synthesis. Located in the ideal oligo position, 2'-O-methyl (OMe) oligo modifications display nuclease resistance, fewer off-target effects, and slightly increased hybridization affinities. These phosphoramidites are commonly used for oligos designed for antisense, siRNA, aptamer, or gRNA-based research. The 'standard grade' marking denotes a baseline level of purity verified with analytical methods, and proven to be suitable for most oligo synthesis requirements. This product is supplied in a 30-mL amber bottle with a 20-400 finish neck style, which is compatible with most Expedite synthesizers.
Features: • Full chemical name—5'-O-(4,4'-Dimethoxytrityl)-N6-phenoxyacetyl-2'-O-methyl-adenosine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite • Molecular formula—C49H56N7O9P • Base—A • Base Protection—PAC • Formula weight—918.0 g/mol • CAS number—128219-82-9 • HPLC purity—≥98.0% • 31P NMR purity—≥98.0%
For Research Use Only. Not for use in diagnostic procedures.