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Proteintech
IST1 Polyclonal Antibody
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Product Details
51002-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
IST1 Fusion Protein Ag0721 (1-364 aa encoded by BC000430)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MLGSGFKAE RLRVNLRLVI NRLKLLEKKK TELAQKARKE IADYLAAGKD ERARIRVEHI IREDYLVEAM EILELYCDLL LARFGLIQSM KELDSGLAES VSTLIWAAPR LQSEVAELKI VADQLCAKYS KEYGKLCRTN QIGTVNDRLM HKLSVEAPPK ILVERYLIEI AKNYNVPYEP DSVVMAEAPP GVETDLIDVG FTDDVKKGGP GRGGSGGFTA PVGGPDGTVP MPMPMPMPMP SANTPFSYPL PKGPSDFNGL PMGTYQAFPN IHPPQIPATP PSYESMTLML IRISLLHRLL VLDPSQKPLQ SFLPDLQITM TTLSYQSCHL CQTHYQLHLL VPAPQHLKTL TLMIFPGGLK S (1-364 aa encoded by BC000430)
Target Information
Proposed to be involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Charged multivesicular body protein 8; CHMP8; hIST1; increased sodium tolerance 1 homolog; IST1 homolog; IST1, endosomal sorting complex required for transport-III component; IST1, ESCRT-III associated factor; KIAA0174; MGC117220; overexpressed in lung cancer 1; pm28; Putative MAPK-activating protein PM28; unnamed protein product
Gene Aliases: CHMP8; IST1; KIAA0174; OLC1
UniProt ID: (Human) P53990
Entrez Gene ID: (Human) 9798
protein localization
protein transport
multivesicular body assembly
establishment of protein localization
positive regulation of proteolysis
collateral sprouting
positive regulation of collateral sprouting
cell division
cytoskeleton-dependent cytokinesis
midbody abscission
ESCRT III complex disassembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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