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Proteintech
Growth hormone Polyclonal Antibody
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Product Details
55243-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
0.43 mg/mL
Amount
64.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody has no cross reaction to CSH1.
Target Information
Human growth hormone (hGH) is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The GH1 gene, along with 4 additional related genes, is located at the growth hormone locus on chromosome 17. The five genes share a remarkably high degree of sequence identity. Alternative splicing results in 5 isoforms ranging from approximately 19 kDa to 24 kDa. HGH is produced by the somatotroph cells in the pituitary. It acts through binding to membrane receptors that belong to the cytokine receptor subfamily. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. Mutations or deletions in the gene lead to growth hormone deficiency and short stature.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: GH; GH1; Growth hormone; Growth hormone 1; growth hormone B5; HGH; Pituitary growth hormone; rHGH; Somatotropin; unnamed protein product
Gene Aliases: GH; GH-N; GH1; GHB5; GHN; hGH-N; IGHD1A; IGHD1B; IGHD2
UniProt ID: (Human) P01241
Entrez Gene ID: (Human) 2688
positive regulation of receptor internalization
JAK-STAT cascade
positive regulation of glucose transport
cytokine-mediated signaling pathway
response to nutrient levels
response to estradiol
positive regulation of multicellular organism growth
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of MAPK cascade
positive regulation of insulin-like growth factor receptor signaling pathway
positive regulation of JAK-STAT cascade
animal organ development
positive regulation of protein kinase B signaling
growth hormone receptor signaling pathway
JAK-STAT cascade involved in growth hormone signaling pathway
negative regulation of growth hormone receptor signaling pathway
bone maturation
receptor signaling pathway via STAT
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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