Metadherin Antibody (21H9L18), ABfinity™ Rabbit Monoclonal

Catalog number: 701171

Invitrogen™  Related applications: Cellular Imaging | Protein Assays and Analysis

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Description

This antibody is predicted to react with non-human primate, mouse and rat based on sequence homology.

ABfinity™ recombinant antibodies are rabbit monoclonal antibodies, unmatched for producing superior results. ABfinity™ antibodies are developed by immunizing animals, screening for functionality, cloning the immunogen-specific antibody genes into high-level mammalian expression vectors, produced on a large scale, and purified with Protein A.

ABfinity™ monoclonal antibodies resemble rabbit monoclonals isolated from serum or produced by hybridomas, but demonstrate greater specificity and sensitivity. Because ABfinity™ recombinant antibodies are derived from cloned DNA sequences of the heavy and light antibody chains, they are not susceptible to cell-line drift or lot-to-lot variation, thus allowing for peak specificity and performance.

Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain.



Metadherin (MTDH) was originally identified as an oncogene, and plays a role in promoting proliferation, invasion, survival, and enhancing chemoresistance. Expression of MTDH is associated with Ha-ras, PI3K/Akt, NF- kappaB and Wnt/ beta-catenin signaling pathways. Immunoflurescence and histochemical analysis has shown perinuclear, nucleolar, and cytoplasmic staining, while upregulated MTDH expression has been shown to enhance nuclear localization. The protein has three putative lysine-rich nuclear localization signals and this antibody has been raised specifically against the NLS3 region.
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Reactivity: Human
Validated Application: ELISA, Western Blot, Immunocytochemistry
Host Species: Rabbit
SubClass (Isotype): IgG
Clonality: Monoclonal
Antibody Fragment: Whole Antibody
Gene ID: 92140
Gene Symbol: MTDH
Accession Number: Q86UE4
Label or Dye: Unconjugated
Purification: Affinity Purified
Concentration: 0.5 mg⁄ml
Form: Liquid
Mass: 100 µg
Product Size: 100 µg
Protein Family: Cell Adhesion Proteins
Volume (Metric): 200 µl
Shipping Condition: Wet Ice

Contents & storage

2 - 8°C for up to 1 month, -20°C for long storage.


Avoid repeated freezing and thawing.

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