Search
NeoBiotechnologies
Sarcomeric Actinin Alpha 2/ACTN2 Recombinant Mouse Monoclonal Antibody (rACTN2/8177)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
{{$ctrl.translations['antibody.pdp.skuNotes.additionalInformation'] || 'Additional Information'}}:
{{$ctrl.translations['antibody.pdp.skuNotes.additionalInformation']}}:
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
88-MSM13-P0
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
rACTN2/8177
Immunogen
A recombinant fragment (aa557-692) of human ACTN2 protein.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
200 µg/mL
Amount
20 µg
Purification
Protein A/G
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Positive Control:Human skeletal or cardiac muscle.
Cellular Location: Cytoplasm.
Target Information
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it i involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: alpha-actinin skeletal muscle; F-actin cross-linking protein; unnamed protein product
Gene Aliases: CMD1AA; CMH23; CMYO8; CMYP8; MPD6; MYOCOZ
UniProt ID: (Human) P35609
Entrez Gene ID: (Human) 88
transcription coactivator activity
integrin binding
calcium ion binding
protein binding
phosphatidylinositol-4,5-bisphosphate binding
cytoskeletal protein binding
structural constituent of muscle
protein domain specific binding
LIM domain binding
titin binding
identical protein binding
ion channel binding
actin filament binding
FATZ binding
titin Z domain binding
structural constituent of postsynaptic actin cytoskeleton
channel activator activity
cell adhesion
microspike assembly
actin cytoskeleton organization
regulation of membrane potential
regulation of apoptotic process
negative regulation of potassium ion transport
positive regulation of potassium ion transport
sarcomere organization
positive regulation of transcription, DNA-templated
focal adhesion assembly
anatomical structure formation involved in morphogenesis
actin filament uncapping
muscle cell development
cardiac muscle cell development
protein localization to plasma membrane
phospholipase C-activating angiotensin-activated signaling pathway
fibril organization
postsynaptic actin cytoskeleton organization
negative regulation of protein localization to cell surface
positive regulation of endocytic recycling
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support